5-Chlorothieno[2,3-d][1,2,3]thiadiazole-6-carboxylic acid

Base Information

Chemical Name:5-Chlorothieno[2,3-d][1,2,3]thiadiazole-6-carboxylic acid
CAS No.:192878-32-3
Molecular Formula:C₅HClN₂O₂S₂
Molecular Weight:220.66
Hs Code.:
European Community (EC) Number:826-436-9
Mol file:192878-32-3.mol

Synonyms:5-chlorothieno[2,3-d][1,2,3]thiadiazole-6-carboxylic acid;192878-32-3;5-Chlorothieno[2,3-d]thiadiazole-6-carboxylic acid;starbld0029520;AP-836/41220364;SCHEMBL8601488;5-chlorothieno[2,3-d]1,2,3-thiadiazole-6-carboxylic acid;SULMCWUDFGQREH-UHFFFAOYSA-N;CS-0249150;EN300-4263313

Suppliers and Price of 5-Chlorothieno[2,3-d][1,2,3]thiadiazole-6-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
5-Chlorothieno[2,3-d][1,2,3]thiadiazole-6-carboxylicacid
5g
$ 1234.00

Total 2 raw suppliers

Chemical Property of 5-Chlorothieno[2,3-d][1,2,3]thiadiazole-6-carboxylic acid

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:219.9167973
Heavy Atom Count:12
Complexity:218

Purity/Quality:

99% ^*data from raw suppliers

5-Chlorothieno[2,3-d][1,2,3]thiadiazole-6-carboxylicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1(=C(SC2=C1SN=N2)Cl)C(=O)O

Technology Process of 5-Chlorothieno[2,3-d][1,2,3]thiadiazole-6-carboxylic acid

There total 10 articles about 5-Chlorothieno[2,3-d][1,2,3]thiadiazole-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 192878-30-1
thieno[2,3-d][1,2,3]thiadiazole-6-carboxylic acid

: 192878-32-3
5-chloro-thieno<2,3-d><1,2,3>thiadiazole-6-carboxylic acid

Guidance literature:: With hexachloroethane; lithium diisopropyl amide; In tetrahydrofuran; 1.) -50 deg C, 1.5 h, 2.) -90 deg C to room temp., 2 h;
DOI:10.1039/a708375k

Reference yield:

: 67-72-1
hexachloroethane

: 192878-30-1
thieno[2,3-d][1,2,3]thiadiazole-6-carboxylic acid

: 192878-32-3
5-chloro-thieno<2,3-d><1,2,3>thiadiazole-6-carboxylic acid

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; water;

Reference yield:

: 28525-50-0
5-oxotetrahydrothiophene-3-carboxylic acid

: 192878-32-3
5-chloro-thieno<2,3-d><1,2,3>thiadiazole-6-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / DCC / diethyl ether / 3.5 h / 5 °C

2: 87 percent / Lawesson's reagent / toluene / 18 h / Heating

3: 90 percent / ethanol / 5 h / Heating

4: 66 percent / SOCl₂ / 1,2-dichloro-ethane / 22 h / 80 °C

5: 98 percent / NaOH, H₂O / ethanol / 1.5 h / Ambient temperature

6: 99 percent / 1.) LDA, 2.) C₂Cl₆ / tetrahydrofuran / 1.) -50 deg C, 1.5 h, 2.) -90 deg C to room temp., 2 h

With Lawessons reagent; sodium hydroxide; thionyl chloride; hexachloroethane; water; dicyclohexyl-carbodiimide; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; ethanol; 1,2-dichloro-ethane; toluene;
DOI:10.1039/a708375k