28525-50-0

Upstream product

• 28525-49-7 mercaptomethyl-succinic acid 
• 100466-79-3 2-[(acetylsulfanyl)methyl]butanedioic acid 
• 97-65-4 2-methylenesuccinic acid 

Downstream Products

• 192879-21-3 tetrahydro-5-oxo-3-thiophenecarboxylic acid methyl ester 
• 140914-51-8 thioparaconic acid chloride 
• 192878-32-3 5-chloro-thieno<2,3-d><1,2,3>thiadiazole-6-carboxylic acid 

Relevant academic research and scientific papers

COMPOSITION COMPRISING BISTHIOLACTONES AND PROCESS FOR TREATING KERATIN MATERIALS USING SAME

The present invention relates to i) a process for treating keratin materials, in particular human keratin fibres, comprising the application of a composition comprising at least one bisthiolactone of formula (I), in particular for shaping keratin fibres and/or straightening/relaxing, ii) a composition comprising the bisthiolactone(s) of formula (I), iii) novel bisthiolactones of formula (I), iv) a process for preparing the novel bisthiolactones of formula (I), and v) the use of said bisthiolactones in cosmetics. In which formula (I), R1, R2, R3, R4, X, X', Y, Y', A, A', B, a, b, c, and d are as defined in the description.

Synthesis of thiolactone building blocks as potential precursors for sustainable functional materials

A library of multifunctional monomers from homocysteine thiolactone and thioparaconic acid were synthesized using straightforward chemistry routes. A generic protocol was developed, leading to multi-gram amounts of the targeted compounds and enabling up-scaling experiments for promising compounds in the area of functional coatings. Aspects considered during selection of targets and synthesis pathways included functional diversity, expected physical properties, sustainability and commercial availability of reagents, as well as feasibility to achieve an industrially relevant process. Trends were observed in yield, physical properties and chemical behavior.

Preparation of carboxythiolactones and their active derivatives

The design of peptidyl immunogens requires that a number of elements be covalently linked to enable the appropriate immune response to occur. Two of these elements are: (a) T-cell sequences which after processing, bind to major histocompatibility complex (MHC) molecules and T-cell receptors and (b) B-cell sequences which embody the constellation of atoms which will ultimately be recognized by the desired antibody. Our concept, designed to effectuate this, involved a single molecule which could conjugate three peptides, potentially in discrete steps, in one pot. Activated carboxythiolactones, hitherto unknown entities, provide such a system: two acyl sites susceptible to nucleophilic attack at disparate rates and a liberated thiol susceptible to electrophilic alkylation. Such a set of thiolactones and their derivatives have been synthesized from inexpensive starting materials and their reactivities are under investigation. If successful, the system will not only obviate the difficult syntheses of longer linear peptides, but will also allow a rapid structural permutation of the various elements.

A new type of plant activator: Synthesis of thieno[2,3-d][1,2,3]-thiadiazole-6-carboxylic acid derivatives via Hurd-Mori cyclization

We present a short and efficient synthesis of the title compounds starting with cheap and readily available methylenebutanedioic acid and thioacetic acid. The optimised sequence allows the large-scale preparation of this new type of plant activator in a few steps. ortho-Lithiation is used for the introduction of substituents into the 5-position. A modified reaction mechanism for the Hurd-Mori reaction is suggested to explain the unexpected aromatisation.

A New Type of Plant Activator: Thieno[2,3-d][1,2,3]thiadiazole-6-carboxylic Acid Derivatives

A short and efficient synthesis of a series of the title compounds is presented starting with methylenebutanedioic acid and thioacetic acid. Using the Hurd-Mori reaction in the key step, the optimised reaction sequence allows the large-scale preparation of this new type of plant activator in a few steps with a high overall yield. Additional functionalisation of the 5-position via directed ortho-lithiation methodology is also described.

Microbicides

The invention relates to novel microbicidal and plant-immunising compounds of formula I STR1 wherein: X is hydrogen, halogen, C1 -C4 alkyl, SR8, N(R9)R10, CH2 OH, CHO or COOR8 ; R8 to R10 are hydrogen, C1 -C4 alkyl, benzyl, C1 -C4 acyl or benzoyl; Z is hydrogen, halogen, or a methyl group that is unsubstituted or to which from 1 to 3 unsubstituted or substituted hetero atoms O, S and/or N are bonded; in free form or in the form of salts. They can be used in crop protection for controlling and preventing disease infestation.