(5,6,7,8-TETRAHYDRO-[1,8]NAPHTHYRIDIN-2-YL)-ACETIC ACID

Base Information

• Chemical Name: (5,6,7,8-TETRAHYDRO-[1,8]NAPHTHYRIDIN-2-YL)-ACETIC ACID
• CAS No.: 445490-61-9
• Molecular Formula: C10H12N2O2
• Molecular Weight: 192.217
• Hs Code.: 2933990090
• Mol file: 445490-61-9.mol

Synonyms:(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-acetic acid

Chemical Property of (5,6,7,8-TETRAHYDRO-[1,8]NAPHTHYRIDIN-2-YL)-ACETIC ACID

Chemical Property:

• PSA: 62.22000
• LogP: 1.20480

Purity/Quality:

97% ^*data from raw suppliers

5,6,7,8-Tetrahydro-1,8-naphthyridin-2-aceticacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5,6,7,8-TETRAHYDRO-[1,8]NAPHTHYRIDIN-2-YL)-ACETIC ACID

There total 12 articles about (5,6,7,8-TETRAHYDRO-[1,8]NAPHTHYRIDIN-2-YL)-ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

ethyl (5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)acetate (721920-80-5) → 2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethanol (445490-61-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 15 - 20 ℃; for 4.5h; Inert atmosphere;

Reference yield:

4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran (96042-30-7) + 7-ethoxycarbonylmethyl-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester (243641-38-5) → 2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethanol (445490-61-9)

Guidance literature:

With sodium hydroxide; trifluoroacetic acid; In methanol; water;

Reference yield:

2-Aminonicotinaldehyde (7521-41-7) → 2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethanol (445490-61-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 99 percent / L-proline

2: 74 percent / H₂ / Pd/C / ethanol

3: 50 percent / NaH / tetrahydrofuran

4: LDA / tetrahydrofuran / 0 °C

5: NaOH / methanol

6: TFA / CH₂Cl₂

With sodium hydroxide; hydrogen; sodium hydride; trifluoroacetic acid; L-proline; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2005.01.028

upstream raw materials:

(8-N-Boc-5,6,7,8-tetrahydro[1,8]naphthyridin-2-yl)acetic acid

2-aminopyridine

2-Aminonicotinaldehyde

N-tert-butyl-2-aminopyridine