Technology Process of 2,2,5-trimethyl-4-(2-phenylethyl)-1,3-dioxane
There total 5 articles about 2,2,5-trimethyl-4-(2-phenylethyl)-1,3-dioxane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
for 3h;
Ambient temperature;
DOI:10.1021/jo00370a023
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) TiCl4, 2.) KF / 1.) CH2Cl2, -78 deg C, 25 min, 2.) Me2SO, 25 deg C, 10 h
2: 93 percent / H2 / Pd/CaCO3/PbO / ethyl acetate / 1 h / 760 Torr / Ambient temperature
3: 1.) O3/O2, 2.) LiAlH4 / 1.) THF, -78 deg C, 1 min, 2.) THF, 25 deg C, 0.5 h
4: 76 percent / p-toluenesulfonic acid / 3 h / Ambient temperature
With
potassium fluoride; lithium aluminium tetrahydride; hydrogen; oxygen; titanium tetrachloride; toluene-4-sulfonic acid; ozone;
Lindlar catalyst;
In
ethyl acetate;
DOI:10.1021/jo00370a023
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, a) -78 deg C, 0.5 h, b) from -78 deg C to 25 deg C, 0.5 h
2: 0.160 g / KF*2H2O / dimethylformamide / 13 h / 25 °C
3: 93 percent / H2 / Pd/CaCO3/PbO / ethyl acetate / 1 h / 760 Torr / Ambient temperature
4: 1.) O3/O2, 2.) LiAlH4 / 1.) THF, -78 deg C, 1 min, 2.) THF, 25 deg C, 0.5 h
5: 76 percent / p-toluenesulfonic acid / 3 h / Ambient temperature
With
potassium fluoride; lithium aluminium tetrahydride; n-butyllithium; hydrogen; oxygen; toluene-4-sulfonic acid; ozone;
Lindlar catalyst;
In
ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00370a023
