4-Methoxyaniline 3-(2'-Hydroxyphenyl)-3,3-dimethylpropionic Acid Amide

Base Information

• Chemical Name: 4-Methoxyaniline 3-(2'-Hydroxyphenyl)-3,3-dimethylpropionic Acid Amide
• CAS No.: 129967-41-5
• Molecular Formula: C₁₈H₂₁NO₃
• Molecular Weight: 299.37
• Mol file: 129967-41-5.mol

Synonyms:

Chemical Property of 4-Methoxyaniline 3-(2'-Hydroxyphenyl)-3,3-dimethylpropionic Acid Amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Methoxyaniline 3-(2'-Hydroxyphenyl)-3,3-dimethylpropionic Acid Amide

There total 5 articles about 4-Methoxyaniline 3-(2'-Hydroxyphenyl)-3,3-dimethylpropionic Acid Amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2'-Hydroxyphenyl)-3,3-dimethylpropanol (40614-20-8) → 4-Methoxyaniline 3-(2'-Hydroxyphenyl)-3,3-dimethylpropionic Acid Amide (129967-41-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 72 percent / K₂CO₃, KI / acetone / 12 h / Heating

2: 82 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h

3: 72 percent / AgNO₃, aq. KOH / ethanol / 2.5 h

4: 44 percent / dicyclohexylcarbodiimide / 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h

5: hydrogen / Pd/C

With potassium hydroxide; hydrogen; potassium carbonate; silver nitrate; dicyclohexyl-carbodiimide; pyridinium chlorochromate; potassium iodide; dmap; palladium on activated charcoal; In ethanol; dichloromethane; acetone;

DOI:10.1021/jo00310a019

Reference yield:

3-(2'-(Benzyloxy)phenyl)-3,3-dimethylpropionaldehyde (129967-38-0) → 4-Methoxyaniline 3-(2'-Hydroxyphenyl)-3,3-dimethylpropionic Acid Amide (129967-41-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / AgNO₃, aq. KOH / ethanol / 2.5 h

2: 44 percent / dicyclohexylcarbodiimide / 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h

3: hydrogen / Pd/C

With potassium hydroxide; hydrogen; silver nitrate; dicyclohexyl-carbodiimide; dmap; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jo00310a019

Reference yield:

3-(2'-(Benzyloxy)phenyl)-3,3-dimethylpropanol (129967-37-9) → 4-Methoxyaniline 3-(2'-Hydroxyphenyl)-3,3-dimethylpropionic Acid Amide (129967-41-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h

2: 72 percent / AgNO₃, aq. KOH / ethanol / 2.5 h

3: 44 percent / dicyclohexylcarbodiimide / 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h

4: hydrogen / Pd/C

With potassium hydroxide; hydrogen; silver nitrate; dicyclohexyl-carbodiimide; pyridinium chlorochromate; dmap; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jo00310a019

upstream raw materials:

4-Methoxyaniline 3-(2'-(Benzyloxy)phenyl)-3,3-dimethylpropionic Acid Amide

3-(2'-Hydroxyphenyl)-3,3-dimethylpropanol

3-(2'-(Benzyloxy)phenyl)-3,3-dimethylpropionaldehyde

3-(2'-(Benzyloxy)phenyl)-3,3-dimethylpropanol