3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-5-methylisoxazole

Base Information

• Chemical Name: 3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-5-methylisoxazole
• CAS No.: 120402-02-0
• Molecular Formula: C₁₇H₁₅NO₃
• Molecular Weight: 281.311
• Mol file: 120402-02-0.mol

Synonyms:

Chemical Property of 3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-5-methylisoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-5-methylisoxazole

There total 4 articles about 3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-5-methylisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

mofezolac (78967-07-4) → 3,4-bis(4-hydroxyphenyl)-5-methylisoxazole (120402-04-2) + 4-(4-hydroxyphenyl)-3-(4-methoxyphenyl)-5-methylisoxazole (120402-03-1) + 3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-5-methylisoxazole (120402-02-0)

Guidance literature:

With pyridine hydrochloride; at 170 - 180 ℃; for 4h;

DOI:10.1248/cpb.36.3142

Reference yield:

C22H25NO5 → 3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-5-methylisoxazole (120402-02-0)

Guidance literature:

With sulfuric acid; In tetrahydrofuran; hexane; for 1h; Yield given; Heating;

DOI:10.1248/cpb.36.3142

Reference yield:

4-methoxybenzyl 4-(2-tetrahydropyranyloxy)phenyl ketone (25026-86-2) → 3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-5-methylisoxazole (120402-02-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 64 percent / hydroxylamine hidrochloride, KOH / tetrahydrofuran; ethanol / Ambient temperature

2: n-BuLi / hexane; tetrahydrofuran / 1 h / Ambient temperature

3: concentrated H₂SO₄ / tetrahydrofuran; hexane / 1 h / Heating

With potassium hydroxide; n-butyllithium; sulfuric acid; hydroxylamine hydrochloride; In tetrahydrofuran; ethanol; hexane;

DOI:10.1248/cpb.36.3142

upstream raw materials:

mofezolac

4-methoxybenzyl 4-(2-tetrahydropyranyloxy)phenyl ketone

1-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethanone

Downstream raw materials:

<3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-5-isoxazolyl>acetic acid

4-(4-Methoxy-phenyl)-5-methyl-3-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-isoxazole

Refernces