4-methoxybenzyl 4-(2-tetrahydropyranyloxy)phenyl ketone

Base Information

• Chemical Name: 4-methoxybenzyl 4-(2-tetrahydropyranyloxy)phenyl ketone
• CAS No.: 25026-86-2
• Molecular Formula: C₂₀H₂₂O₄
• Molecular Weight: 326.392
• Mol file: 25026-86-2.mol

Synonyms:

Chemical Property of 4-methoxybenzyl 4-(2-tetrahydropyranyloxy)phenyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methoxybenzyl 4-(2-tetrahydropyranyloxy)phenyl ketone

There total 1 articles about 4-methoxybenzyl 4-(2-tetrahydropyranyloxy)phenyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3,4-dihydro-2H-pyran (110-87-2) + 1-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethanone (3669-46-3) → 4-methoxybenzyl 4-(2-tetrahydropyranyloxy)phenyl ketone (25026-86-2)

Guidance literature:

With toluene-4-sulfonic acid; for 6h; Ambient temperature;

DOI:10.1248/cpb.36.3142

Reference yield: 64.0%

4-methoxybenzyl 4-(2-tetrahydropyranyloxy)phenyl ketone (25026-86-2) → 4-methoxybenzyl 4-(2-tetrahydropyranyloxy)phenyl ketoxime (120402-00-8)

Guidance literature:

With potassium hydroxide; hydroxylamine hydrochloride; In tetrahydrofuran; ethanol; Ambient temperature;

DOI:10.1248/cpb.36.3142

Reference yield:

4-methoxybenzyl 4-(2-tetrahydropyranyloxy)phenyl ketone (25026-86-2) → 3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-5-methylisoxazole (120402-02-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 64 percent / hydroxylamine hidrochloride, KOH / tetrahydrofuran; ethanol / Ambient temperature

2: n-BuLi / hexane; tetrahydrofuran / 1 h / Ambient temperature

3: concentrated H₂SO₄ / tetrahydrofuran; hexane / 1 h / Heating

With potassium hydroxide; n-butyllithium; sulfuric acid; hydroxylamine hydrochloride; In tetrahydrofuran; ethanol; hexane;

DOI:10.1248/cpb.36.3142

upstream raw materials:

3,4-dihydro-2H-pyran

1-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethanone

Downstream raw materials:

4-methoxybenzyl 4-(2-tetrahydropyranyloxy)phenyl ketoxime

3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-5-methylisoxazole

<3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-5-isoxazolyl>acetic acid

4-(4-Methoxy-phenyl)-5-methyl-3-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-isoxazole