1H-Pyrazole-4-carboxylic acid, 1-[6-(2-hydroxyphenyl)-2-pyridinyl]-5-(trifluoromethyl)-, ethyl ester

Base Information

Chemical Name:1H-Pyrazole-4-carboxylic acid, 1-[6-(2-hydroxyphenyl)-2-pyridinyl]-5-(trifluoromethyl)-, ethyl ester
CAS No.:1128268-02-9
Molecular Formula:C25H20N2O4
Molecular Weight:377.323
Hs Code.:

Synonyms:ethyl 1-(diphenylamino)-4,5-dioxo-2-phenyl-4,5-dihydro-1H-pyrrole-3-carboxylate;

Suppliers and Price of 1H-Pyrazole-4-carboxylic acid, 1-[6-(2-hydroxyphenyl)-2-pyridinyl]-5-(trifluoromethyl)-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 6 raw suppliers

Chemical Property of 1H-Pyrazole-4-carboxylic acid, 1-[6-(2-hydroxyphenyl)-2-pyridinyl]-5-(trifluoromethyl)-, ethyl ester

Chemical Property:

Boiling Point:565.1 °C at 760 mmHg
Flash Point:295.6 °C
Density:1.328 g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-4-carboxylic acid, 1-[6-(2-hydroxyphenyl)-2-pyridinyl]-5-(trifluoromethyl)-, ethyl ester

There total 3 articles about 1H-Pyrazole-4-carboxylic acid, 1-[6-(2-hydroxyphenyl)-2-pyridinyl]-5-(trifluoromethyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

: 1128268-00-7
ethyl 1-(6-chloropyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 269409-97-4
2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

: 1128268-02-9
ethyl 1-[6-(2-hydroxylphenyl)pyridine-2-yl]-5-trifluoromethyl-1H-pyrazole-4-carboxylate

Guidance literature:: With sodium carbonate; In 1,2-dimethoxyethane; water; at 90 ℃; for 3h;

Reference yield:

: 1128268-00-7
ethyl 1-(6-chloropyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 89466-08-0
2-hydroxyphenyl boronic acid

: 1128268-02-9
ethyl 1-[6-(2-hydroxylphenyl)pyridine-2-yl]-5-trifluoromethyl-1H-pyrazole-4-carboxylate

Guidance literature:: With sodium carbonate; trans-bis(triphenylphosphine)palladium dichloride; In water; acetonitrile; at 70 ℃; for 3h;

Reference yield:

: 571-55-1
ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate

: 1128268-02-9
ethyl 1-[6-(2-hydroxylphenyl)pyridine-2-yl]-5-trifluoromethyl-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / acetonitrile / 0.83 h / 60 °C

2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / acetonitrile; water / 3 h / 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; triethylamine; In water; acetonitrile;