(2S,3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride

Base Information

• Chemical Name: (2S,3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride
• CAS No.: 944716-73-8
• Molecular Formula: C9H18N2O2.HCl
• Molecular Weight: 222.715
• Mol file: 944716-73-8.mol

Synonyms:(2S,3S)-3-AMino-N-cyclopropyl-2-hydroxyhexanaMide HCl; Telaprevir Intermediate 4

Chemical Property of (2S,3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride

Chemical Property:

• Vapor Pressure: 0Pa at 25℃
• PSA: 78.84000
• Density: 1.17 at 20℃
• LogP: 2.09590
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

(2S,3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S,3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride

There total 11 articles about (2S,3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

→ (2S,3S)-N-cyclopropyl-3-amino-2-hydroxyhexanoic acid amide hydrochloride (944716-73-8,1166397-39-2)

Guidance literature:

In hexane; isopropyl alcohol; at 0 - 60 ℃; for 6h; Purification / work up;

Reference yield: 84.0%

C9H16N4O2 → (2S,3S)-N-cyclopropyl-3-amino-2-hydroxyhexanoic acid amide hydrochloride (944716-73-8,1166397-39-2)

Guidance literature:

C₉H₁₆N₄O₂; With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2.5h; under 750.075 Torr;

With hydrogenchloride; In methanol; water;

DOI:10.1002/ejoc.201403069

Reference yield: 80.0%

(2S,3S)-N-cyclopropyl-3-(tert-butoxycarbonyl)amino-2-hydroxyhexanoic acid amide (944716-71-6) → (2S,3S)-N-cyclopropyl-3-amino-2-hydroxyhexanoic acid amide hydrochloride (944716-73-8,1166397-39-2)

Guidance literature:

With hydrogenchloride; water; isopropyl alcohol; at 60 ℃; for 24h; Product distribution / selectivity;

upstream raw materials:

(2S,3S)-3-amino-3-deutero-N-cyclopropyl-2-hydroxyhexanamide deoxycholic acid salt

(2S,3S)-N-cyclopropyl-3-(tert-butoxycarbonyl)amino-2-hydroxyhexanoic acid amide

(4S,5S)-N-cyclopropyl-2-isopropyl-4-propyl-4,5-dihydro-1,3-oxazole-5-carboxamide

(4S,5S)-N-cyclopropyl-2-methyl-4-propyl-4,5-dihydro-1,3-oxazole-5-carboxamide

Downstream raw materials:

(2S,4R)-tert-butyl 2-((2S,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-ylcarbamoyl)-4-(7-methoxy-2-(1H-pyrazol-1-yl)quinolin-4-yloxy)pyrrolidine-1-carboxylate

C₃₆H₅₅N₇O₆

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

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