944716-71-6

Basic information

• Product Name: N-[(1S)-1-[(1S)-2-(Cyclopropylamino)-1-hydroxy-2-oxoethyl]butyl]carbamic acid tert-butyl ester
• Synonyms: N-[(1S)-1-[(1S)-2-(Cyclopropylamino)-1-hydroxy-2-oxoethyl]butyl]carbamic acid tert-butyl ester;CarbaMic acid, N-[(1S)-1-[(1S)-2-(cyclopropylaMino)-1-hydroxy-2-oxoethyl]butyl]-, 1,1-diMethylethyl ester;tert-butyl ((2R,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl)carbamate;tert-Butyl ((2S,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl)carbamate
• CAS NO: 944716-71-6
• Molecular Formula: C₁₄H₂₆N₂O₄
• Molecular Weight: 286.36724
• Mol File: 944716-71-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-[(1S)-1-[(1S)-2-(Cyclopropylamino)-1-hydroxy-2-oxoethyl]butyl]carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(1S)-1-[(1S)-2-(Cyclopropylamino)-1-hydroxy-2-oxoethyl]butyl]carbamic acid tert-butyl ester(944716-71-6)
• EPA Substance Registry System: N-[(1S)-1-[(1S)-2-(Cyclopropylamino)-1-hydroxy-2-oxoethyl]butyl]carbamic acid tert-butyl ester(944716-71-6)

Safety Data

• Hazardous Substances Data: 944716-71-6(Hazardous Substances Data)

Upstream product

• 209398-26-5 (3S)-3-(tert-butoxycarbonylamino)-2-hydroxyhexanoic acid 
• 765-30-0 Cyclopropylamine 
• 944716-69-2 (2S,3S)-N-tert-butoxycarbonyl-3-amino-2-hydroxy-hexanoic acid 

Downstream Products

• 944716-73-8 (2S,3S)-N-cyclopropyl-3-amino-2-hydroxyhexanoic acid amide hydrochloride 
• 850252-34-5 (3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride 

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PROCESS FOR PRODUCTION OF BETA-AMINO-ALPHA-HYDROXY ACID AMIDE DERIVATIVE

Provided is a process for production of a β-amino-α-hydroxy carboxamide derivative that is important in production of drugs or the like. In the presence of a predetermined solvent, a β-(N-protected)amino-α-hydroxycarboxylic acid is reacted with an amine to conversion to a β-(N-protected)amino-α-hydroxy carboxamide derivative; then the derivative is deprotected for conversion to a β-amino-α-hydroxy carboxamide derivative; and the derivative is crystallized using a protic solvent to obtain a crystal. The high-purity β-amino-α-hydroxy carboxamide derivative can be stably produced on an industrial scale by the process.