Technology Process of 5-Chloro-2-methyl-2,3-dihydrodibenzo[2,3:6,7]oxepino[4,5-c]pyrrole-(2H)-one
There total 8 articles about 5-Chloro-2-methyl-2,3-dihydrodibenzo[2,3:6,7]oxepino[4,5-c]pyrrole-(2H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dmap; acetic anhydride;
In
dichloromethane;
at 30 - 50 ℃;
Reagent/catalyst;
Temperature;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate; copper / o-xylene / 25 - 30 °C / Reflux
2.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 40 - 50 °C
2.2: 0 - 30 °C
3.1: potassium tert-butylate / toluene / 15 - 30 °C / Inert atmosphere
3.2: 0 - 5 °C / pH 2 - 2.5
4.1: phosphorus pentoxide; phosphoric acid / 100 - 120 °C
With
thionyl chloride; phosphoric acid; potassium tert-butylate; phosphorus pentoxide; copper; potassium carbonate;
In
o-xylene; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: caesium carbonate / copper(l) chloride; dimethylaminoacetic acid / 1,4-dioxane / 110 - 115 °C
1.2: 5 h / 25 - 65 °C
2.1: hydrogenchloride / dichloromethane; water / pH 1.5
2.2: 0.75 h / 0 - 15 °C
3.1: potassium tert-butylate / toluene / 3 h / 20 °C
3.2: 3 h / 20 °C
4.1: phosphorus pentoxide; phosphoric acid / 96 h / 115 - 120 °C
With
hydrogenchloride; phosphorus pentoxide; phosphoric acid; potassium tert-butylate; caesium carbonate;
dimethylaminoacetic acid; copper(l) chloride;
In
1,4-dioxane; dichloromethane; water; toluene;