N^α-(9-fluorenylmethyloxycarbonyl)-O-phosphono>tyrosine

Base Information

Chemical Name:N^α-(9-fluorenylmethyloxycarbonyl)-O-phosphono>tyrosine
CAS No.:158817-09-5
Molecular Formula:C₃₄H₄₆NO₈PSi₂
Molecular Weight:683.886
Hs Code.:

N<sup>α</sup>-(9-fluorenylmethyloxycarbonyl)-O-<bis<2-(trimethylsilyl)ethyl>phosphono>tyrosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N^α-(9-fluorenylmethyloxycarbonyl)-O-phosphono>tyrosine

Chemical Property:

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Technology Process of N^α-(9-fluorenylmethyloxycarbonyl)-O-phosphono>tyrosine

There total 7 articles about N^α-(9-fluorenylmethyloxycarbonyl)-O-phosphono>tyrosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 158817-09-5
N^α-(9-fluorenylmethyloxycarbonyl)-O-phosphono>tyrosine

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / Et₃N / diethyl ether / Ambient temperature

2: tertrazole / tetrahydrofuran / 2 h / Ambient temperature

3: 1.) tert-BuOOH, 2.) 5percent aq. KHSO₄ / 1.) THF, 0 deg C, 3 h, 2.) EtOAc

With 1H-tetrazole; tert.-butylhydroperoxide; potassium hydrogensulfate; triethylamine; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo00101a029

Reference yield:

: 112883-29-1,92954-90-0
N-Fmoc-Tyr-OH

: 158817-09-5
N^α-(9-fluorenylmethyloxycarbonyl)-O-phosphono>tyrosine

Guidance literature:: Multi-step reaction with 3 steps

1: NMM / tetrahydrofuran / 0.25 h / Ambient temperature

2: tertrazole / tetrahydrofuran / 2 h / Ambient temperature

3: 1.) tert-BuOOH, 2.) 5percent aq. KHSO₄ / 1.) THF, 0 deg C, 3 h, 2.) EtOAc

With 4-methyl-morpholine; 1H-tetrazole; tert.-butylhydroperoxide; potassium hydrogensulfate; In tetrahydrofuran;
DOI:10.1021/jo00101a029

Reference yield:

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 158817-09-5
N^α-(9-fluorenylmethyloxycarbonyl)-O-phosphono>tyrosine

Guidance literature:: Multi-step reaction with 4 steps

1: 73.4 percent / 10percent aq. NaHCO₃ / acetone / 20 h / Ambient temperature

2: NMM / tetrahydrofuran / 0.25 h / Ambient temperature

3: tertrazole / tetrahydrofuran / 2 h / Ambient temperature

4: 1.) tert-BuOOH, 2.) 5percent aq. KHSO₄ / 1.) THF, 0 deg C, 3 h, 2.) EtOAc

With 4-methyl-morpholine; 1H-tetrazole; tert.-butylhydroperoxide; potassium hydrogensulfate; sodium hydrogencarbonate; In tetrahydrofuran; acetone;
DOI:10.1021/jo00101a029