Technology Process of Nα-(9-fluorenylmethyloxycarbonyl)-O-phosphono>tyrosine
There total 7 articles about Nα-(9-fluorenylmethyloxycarbonyl)-O-phosphono>tyrosine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 81 percent / Et3N / diethyl ether / Ambient temperature
2: tertrazole / tetrahydrofuran / 2 h / Ambient temperature
3: 1.) tert-BuOOH, 2.) 5percent aq. KHSO4 / 1.) THF, 0 deg C, 3 h, 2.) EtOAc
With
1H-tetrazole; tert.-butylhydroperoxide; potassium hydrogensulfate; triethylamine;
In
tetrahydrofuran; diethyl ether;
DOI:10.1021/jo00101a029
- Guidance literature:
-
Multi-step reaction with 3 steps
1: NMM / tetrahydrofuran / 0.25 h / Ambient temperature
2: tertrazole / tetrahydrofuran / 2 h / Ambient temperature
3: 1.) tert-BuOOH, 2.) 5percent aq. KHSO4 / 1.) THF, 0 deg C, 3 h, 2.) EtOAc
With
4-methyl-morpholine; 1H-tetrazole; tert.-butylhydroperoxide; potassium hydrogensulfate;
In
tetrahydrofuran;
DOI:10.1021/jo00101a029
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 73.4 percent / 10percent aq. NaHCO3 / acetone / 20 h / Ambient temperature
2: NMM / tetrahydrofuran / 0.25 h / Ambient temperature
3: tertrazole / tetrahydrofuran / 2 h / Ambient temperature
4: 1.) tert-BuOOH, 2.) 5percent aq. KHSO4 / 1.) THF, 0 deg C, 3 h, 2.) EtOAc
With
4-methyl-morpholine; 1H-tetrazole; tert.-butylhydroperoxide; potassium hydrogensulfate; sodium hydrogencarbonate;
In
tetrahydrofuran; acetone;
DOI:10.1021/jo00101a029
