Technology Process of (6E,17Z,28E)-5,3'-bis((4-methoxybenzyloxy)methyl)-2,4,31,33-tetraoxatetratriaconta-6,17,28-triene
There total 7 articles about (6E,17Z,28E)-5,3'-bis((4-methoxybenzyloxy)methyl)-2,4,31,33-tetraoxatetratriaconta-6,17,28-triene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydrogen bromide / water; toluene / 48 h / Inert atmosphere; Reflux
2.1: 1H-imidazole / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
3.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
4.1: toluene-4-sulfonic acid / methanol / 1 h / 0 - 20 °C / Inert atmosphere
5.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 6 h / Inert atmosphere; Reflux
6.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane; dimethyl sulfoxide / 6 h / 20 °C / Inert atmosphere
7.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.75 h / 0 - 20 °C / Inert atmosphere
7.2: 0.75 h / 0 - 20 °C / Inert atmosphere
With
1H-imidazole; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; potassium tert-butylate; hydrogen bromide; sodium hexamethyldisilazane; toluene-4-sulfonic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; toluene;
7.2: Wittig reaction;
DOI:10.1016/j.tetasy.2012.04.004
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 1H-imidazole / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
2.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
3.1: toluene-4-sulfonic acid / methanol / 1 h / 0 - 20 °C / Inert atmosphere
4.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 6 h / Inert atmosphere; Reflux
5.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane; dimethyl sulfoxide / 6 h / 20 °C / Inert atmosphere
6.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.75 h / 0 - 20 °C / Inert atmosphere
6.2: 0.75 h / 0 - 20 °C / Inert atmosphere
With
1H-imidazole; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; potassium tert-butylate; sodium hexamethyldisilazane; toluene-4-sulfonic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;
6.2: Wittig reaction;
DOI:10.1016/j.tetasy.2012.04.004
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: quinoline; hydrogen / ethyl acetate / 6 h / 20 °C
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
3.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 6 h / Inert atmosphere; Reflux
4.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane; dimethyl sulfoxide / 6 h / 20 °C / Inert atmosphere
5.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.75 h / 0 - 20 °C / Inert atmosphere
5.2: 0.75 h / 0 - 20 °C / Inert atmosphere
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; quinoline; hydrogen; sodium hexamethyldisilazane; N-ethyl-N,N-diisopropylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; ethyl acetate;
5.2: Wittig reaction;
DOI:10.1016/j.tetasy.2012.04.004
