trans-2-Methylamino-cyclohexanol hydrochloride

Base Information

• Chemical Name: trans-2-Methylamino-cyclohexanol hydrochloride
• CAS No.: 260392-65-2
• Molecular Formula: C₇H₁₅NO*ClH
• Molecular Weight: 165.663
• Hs Code.: 2922190090
• Mol file: 260392-65-2.mol

Synonyms:TRANS-2-METHYLAMINO-CYCLOHEXANOL HYDROCHLORIDE;(1S,2S)-2-(MethylaMino)cyclohexanol hydrochloride;(1R,2R)-2-(Methylamino)Cyclohexanol Hydrochloride (1:1)

Chemical Property of trans-2-Methylamino-cyclohexanol hydrochloride

Chemical Property:

• Vapor Pressure: 0.0032mmHg at 25°C
• Boiling Point: 251.5 °C at 760 mmHg
• Flash Point: 105.9 °C
• PSA: 32.26000
• LogP: 1.70220
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

trans-2-Methylamino-cyclohexanolhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of trans-2-Methylamino-cyclohexanol hydrochloride

There total 4 articles about trans-2-Methylamino-cyclohexanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,2S)-trans-2-(N-benzoyl-N-methyl)amino-1-cyclohexanol (112708-86-8) → (1S,2S)-trans-2-methylamino cyclohexanol hydrochloride (260392-65-2)

Guidance literature:

With hydrogenchloride; for 5h; Yield given; Heating;

Reference yield:

trans-2--cyclohexanol (112708-85-7) → (1R,2R)-trans-2-methylamino cyclohexanol hydrochloride (260392-65-2)

Guidance literature:

With hydrogenchloride; for 5h; Yield given; Heating;

Reference yield:

N-(2-hydroxy-cyclohexyl)-N-methyl-acetamide → cis-2-methylaminocyclohexanol hydrochloride (100868-93-7,112708-87-9,112708-88-0,112789-82-9,260392-65-2)

Guidance literature:

With hydrogenchloride; thionyl chloride; Yield given; Multistep reaction;

upstream raw materials:

rac-trans-2-methylamino-cyclohexanol

trans-2--cyclohexanol

(1S,2S)-trans-2-(N-benzoyl-N-methyl)amino-1-cyclohexanol

Refernces

• 1、 Pracejus, H.,Pracejus, G.,Costisella, B.. "O.N-Bis(diphenylphosphino) Derivatives of Chiral trans- and cis-2-Aminocyclohexanols: Synthesis and Enantioselective Behaviour as Ligands in Rh-based Homogeneous Hydrogenation Catalysts". . p. 235 - 245. Retrieved 2007/10/02.