112708-85-7

Upstream product

• 23755-31-9 (+/-)-N-(trans-2-hydroxy-cyclohexyl)-N-methyl-benzamide 
• 98-88-4 benzoyl chloride 
• 20431-81-6 rac-trans-2-methylamino-cyclohexanol 

Downstream Products

• 23755-31-9 (+/-)-N-(cis-2-hydroxy-cyclohexyl)-N-methyl-benzamide 
• 260392-65-2 (1R,2R)-trans-2-methylamino cyclohexanol hydrochloride 
• 112708-89-1 (1S,2R)-cis-2-(N-methyl)amino-1-cyclohexanol 

Relevant academic research and scientific papers

O.N-Bis(diphenylphosphino) Derivatives of Chiral trans- and cis-2-Aminocyclohexanols: Synthesis and Enantioselective Behaviour as Ligands in Rh-based Homogeneous Hydrogenation Catalysts

trans- and cis-2-Methylamino cyclohexanols (MAC) were prepared in enantiomerically pure forms and transformed into O.N-bis(diphenylphosphino) derivatives ("PONP").An analogous trans-1R;2R-aminocyclohexanol PONP could only be isolated in an impure form, whereas the attempted synthesis of PONP's of diastereomeric trans-2-(N-α-phenylethylamino)-cyclohexanols failed.Cationic Rh(I)-chelates of the new PONP's catalyzed the enantioselective hydrogenation of dehydro-α-acylamino acids with /= 97percent ee.A comparison of the enantiodiscriminating properties of the MAC-PONP's with structurally related chiral ligands leads to surprising conclusions.