Technology Process of 1-(4-chlorophenyl)-3-ethyl-6,7-dimethoxy-4-methylisoquinoline
There total 5 articles about 1-(4-chlorophenyl)-3-ethyl-6,7-dimethoxy-4-methylisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: trifluoroacetic acid / toluene / 1 h / 140 °C / Microwave irradiation
1.2: pH 8
2.1: palladium 10% on activated carbon / 2 h / 180 °C / Neat (no solvent)
With
palladium 10% on activated carbon; trifluoroacetic acid;
In
toluene;
1.1: Pictet-Spengler cyclisation;
DOI:10.1021/ol202565j
- Guidance literature:
-
With
palladium 10% on activated carbon;
at 180 ℃;
for 2h;
Neat (no solvent);
DOI:10.1021/ol202565j
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; sodium t-butanolate; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane / toluene / 20 h / 40 °C / Inert atmosphere
2.1: titanium(IV) isopropylate; ammonia / methanol / 20 °C / Inert atmosphere
2.2: 1 h / 20 °C / Inert atmosphere
3.1: trifluoroacetic acid / toluene / 1 h / 140 °C / Microwave irradiation
3.2: pH 8
4.1: palladium 10% on activated carbon / 2 h / 180 °C / Neat (no solvent)
With
titanium(IV) isopropylate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; palladium 10% on activated carbon; ammonia; trifluoroacetic acid; sodium t-butanolate; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane;
In
methanol; toluene;
3.1: Pictet-Spengler cyclisation;
DOI:10.1021/ol202565j
