(S)-(11Z)-18-(2,4-difluorophenyl)-7-(5-methyI-1H-1,2,4-triazol-1-yl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecine

Base Information

• Chemical Name: (S)-(11Z)-18-(2,4-difluorophenyl)-7-(5-methyI-1H-1,2,4-triazol-1-yl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecine
• CAS No.: 1356008-35-9
• Molecular Formula: C₂₆H₂₃F₂N₇O
• Molecular Weight: 487.512

Synonyms:

Chemical Property of (S)-(11Z)-18-(2,4-difluorophenyl)-7-(5-methyI-1H-1,2,4-triazol-1-yl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(11Z)-18-(2,4-difluorophenyl)-7-(5-methyI-1H-1,2,4-triazol-1-yl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecine

There total 6 articles about (S)-(11Z)-18-(2,4-difluorophenyl)-7-(5-methyI-1H-1,2,4-triazol-1-yl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-difluoronitrobenzene (369-34-6) → (R)-(11Z)-18-(2,4-difluorophenyl)-7-(5-methyI-1H-1,2,4-triazol-1-yl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecine (1356008-34-8) + (S)-(11Z)-18-(2,4-difluorophenyl)-7-(5-methyI-1H-1,2,4-triazol-1-yl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecine (1356008-35-9) + (+)-(11E)-18-(2,4-difluorophenyl)-7-(5-methyI-1H-1,2,4-triazol-1-yl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecine + (-)-(11E)-18-(2,4-difluorophenyl)-7-(5-methyI-1H-1,2,4-triazol-1-yl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecine

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / dimethyl sulfoxide / 48 h / 80 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C

2.2: 0.5 h / 20 °C

3.1: ammonium chloride; iron / methanol / 0.83 h / 65 °C

4.1: 0.75 h / 150 °C

5.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / 1,2-dichloro-ethane / 18 h / 95 °C / Inert atmosphere

5.2: Chiral cel-OJ-H / 35 °C / 75007.5 Torr / Resolution of racemate

With iron; sodium hydride; sodium hydrogencarbonate; ammonium chloride; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In methanol; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

1-(2-Fluoro-4-nitro-phenyl)-5-methyl-1H-[1,2,4]triazole (1185019-89-9) → (R)-(11Z)-18-(2,4-difluorophenyl)-7-(5-methyI-1H-1,2,4-triazol-1-yl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecine (1356008-34-8) + (S)-(11Z)-18-(2,4-difluorophenyl)-7-(5-methyI-1H-1,2,4-triazol-1-yl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecine (1356008-35-9) + (+)-(11E)-18-(2,4-difluorophenyl)-7-(5-methyI-1H-1,2,4-triazol-1-yl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecine + (-)-(11E)-18-(2,4-difluorophenyl)-7-(5-methyI-1H-1,2,4-triazol-1-yl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecine

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C

1.2: 0.5 h / 20 °C

2.1: ammonium chloride; iron / methanol / 0.83 h / 65 °C

3.1: 0.75 h / 150 °C

4.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / 1,2-dichloro-ethane / 18 h / 95 °C / Inert atmosphere

4.2: Chiral cel-OJ-H / 35 °C / 75007.5 Torr / Resolution of racemate

With iron; sodium hydride; ammonium chloride; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

7-(2,4-difluorophenyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione (1263869-66-4) → (R)-(11Z)-18-(2,4-difluorophenyl)-7-(5-methyI-1H-1,2,4-triazol-1-yl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecine (1356008-34-8) + (S)-(11Z)-18-(2,4-difluorophenyl)-7-(5-methyI-1H-1,2,4-triazol-1-yl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecine (1356008-35-9) + (+)-(11E)-18-(2,4-difluorophenyl)-7-(5-methyI-1H-1,2,4-triazol-1-yl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecine + (-)-(11E)-18-(2,4-difluorophenyl)-7-(5-methyI-1H-1,2,4-triazol-1-yl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecine

Guidance literature:

Multi-step reaction with 4 steps

1.1: trichlorophosphate / 2 h / 130 °C / microwave irradiation

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C

3.1: 0.75 h / 150 °C

4.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / 1,2-dichloro-ethane / 18 h / 95 °C / Inert atmosphere

4.2: Chiral cel-OJ-H / 35 °C / 75007.5 Torr / Resolution of racemate

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In 1,2-dichloro-ethane; acetonitrile;

upstream raw materials:

3,4-difluoronitrobenzene

1-(2-Fluoro-4-nitro-phenyl)-5-methyl-1H-[1,2,4]triazole

7-(2,4-difluorophenyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione

2,4-dichloro-7-(2,4-difluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

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