1,5-dimethyl (2R)-2-{7-[(2R)-1,5-dimethoxy-1,5-dioxopentan-2-yl]-4,10-bis({[(2-trifluoromethyl)phenyl]carbamoyl}methyl)-1,4,7,10-tetraazacyclododecan-1-yl}pentanedioate

Base Information

Chemical Name:1,5-dimethyl (2R)-2-{7-[(2R)-1,5-dimethoxy-1,5-dioxopentan-2-yl]-4,10-bis({[(2-trifluoromethyl)phenyl]carbamoyl}methyl)-1,4,7,10-tetraazacyclododecan-1-yl}pentanedioate
CAS No.:1269772-30-6
Molecular Formula:C₄₀H₅₂F₆N₆O₁₀
Molecular Weight:890.877
Hs Code.:

1,5-dimethyl (2R)-2-{7-[(2R)-1,5-dimethoxy-1,5-dioxopentan-2-yl]-4,10-bis({[(2-trifluoromethyl)phenyl]carbamoyl}methyl)-1,4,7,10-tetraazacyclododecan-1-yl}pentanedioate

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Chemical Property of 1,5-dimethyl (2R)-2-{7-[(2R)-1,5-dimethoxy-1,5-dioxopentan-2-yl]-4,10-bis({[(2-trifluoromethyl)phenyl]carbamoyl}methyl)-1,4,7,10-tetraazacyclododecan-1-yl}pentanedioate

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Technology Process of 1,5-dimethyl (2R)-2-{7-[(2R)-1,5-dimethoxy-1,5-dioxopentan-2-yl]-4,10-bis({[(2-trifluoromethyl)phenyl]carbamoyl}methyl)-1,4,7,10-tetraazacyclododecan-1-yl}pentanedioate

There total 3 articles about 1,5-dimethyl (2R)-2-{7-[(2R)-1,5-dimethoxy-1,5-dioxopentan-2-yl]-4,10-bis({[(2-trifluoromethyl)phenyl]carbamoyl}methyl)-1,4,7,10-tetraazacyclododecan-1-yl}pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873200-91-0
(S)-2-bromopentanedioic acid dimethyl ester

: 1269772-29-3
N-[2-(trifluoromethyl)phenyl]-2-[7-({[(2-trifluoromethyl)phenyl]carbamoyl}methyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetamide

: 1269772-30-6
1,5-dimethyl (2R)-2-{7-[(2R)-1,5-dimethoxy-1,5-dioxopentan-2-yl]-4,10-bis({[(2-trifluoromethyl)phenyl]carbamoyl}methyl)-1,4,7,10-tetraazacyclododecan-1-yl}pentanedioate

Guidance literature:: With potassium carbonate; In acetonitrile; at 85 ℃; for 18h; Inert atmosphere; Reflux;
DOI:10.1039/c0dt01232g

Reference yield:

: 3792-04-9
2-chloro-N-[2-(trifluoromethyl)phenyl]acetamide

: 1269772-30-6
1,5-dimethyl (2R)-2-{7-[(2R)-1,5-dimethoxy-1,5-dioxopentan-2-yl]-4,10-bis({[(2-trifluoromethyl)phenyl]carbamoyl}methyl)-1,4,7,10-tetraazacyclododecan-1-yl}pentanedioate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethanol / 18 h / 50 °C / Inert atmosphere

2: potassium carbonate / acetonitrile / 18 h / 85 °C / Inert atmosphere; Reflux

With potassium carbonate; triethylamine; In ethanol; acetonitrile;
DOI:10.1039/c0dt01232g

Reference yield:

: 294-90-6
1,4,7,10-tetraazacyclododecan

: 1269772-30-6
1,5-dimethyl (2R)-2-{7-[(2R)-1,5-dimethoxy-1,5-dioxopentan-2-yl]-4,10-bis({[(2-trifluoromethyl)phenyl]carbamoyl}methyl)-1,4,7,10-tetraazacyclododecan-1-yl}pentanedioate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethanol / 18 h / 50 °C / Inert atmosphere

2: potassium carbonate / acetonitrile / 18 h / 85 °C / Inert atmosphere; Reflux

With potassium carbonate; triethylamine; In ethanol; acetonitrile;
DOI:10.1039/c0dt01232g