(1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2-oxo-5-phenyl-1,2-dihydro-pyridin-3-yl)-carbamic acid benzyl ester

Base Information

• Chemical Name: (1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2-oxo-5-phenyl-1,2-dihydro-pyridin-3-yl)-carbamic acid benzyl ester
• CAS No.: 1025909-49-2
• Molecular Formula: C₃₃H₄₂F₃N₃O₅Si
• Molecular Weight: 645.794
• Mol file: 1025909-49-2.mol

Synonyms:

Chemical Property of (1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2-oxo-5-phenyl-1,2-dihydro-pyridin-3-yl)-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2-oxo-5-phenyl-1,2-dihydro-pyridin-3-yl)-carbamic acid benzyl ester

There total 1 articles about (1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2-oxo-5-phenyl-1,2-dihydro-pyridin-3-yl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-5-iodo-2-oxo-1,2-dihydro-pyridin-3-yl)-carbamic acid benzyl ester (147269-73-6) + phenylboronic acid (98-80-6) → (1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2-oxo-5-phenyl-1,2-dihydro-pyridin-3-yl)-carbamic acid benzyl ester (1025909-49-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; Multistep reaction; 1.) a.) THF, 0.5 h, b.) THF, ethanol, 1 h, 2.) THF, ethanol, reflux, 3 h;

DOI:10.1021/jm00046a015

Reference yield:

(1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2-oxo-5-phenyl-1,2-dihydro-pyridin-3-yl)-carbamic acid benzyl ester (1025909-49-2) → 2-<3-<(benzyloxycarbonyl)amino>-2-oxo-5-phenyl-1,2-dihydro-1-pyridyl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropyl)acetamide (162738-56-9)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.0833333h; Yield given;

DOI:10.1021/jm00046a015

Reference yield:

(1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2-oxo-5-phenyl-1,2-dihydro-pyridin-3-yl)-carbamic acid benzyl ester (1025909-49-2) → {2-Oxo-5-phenyl-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,2-dihydro-pyridin-3-yl}-carbamic acid benzyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h

2: dichloro-acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dimethyl sulfoxide; toluene

With dichloro-acetic acid; tetrabutyl ammonium fluoride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dimethyl sulfoxide; toluene;

DOI:10.1021/jm00046a015

upstream raw materials:

(1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-5-iodo-2-oxo-1,2-dihydro-pyridin-3-yl)-carbamic acid benzyl ester

phenylboronic acid

Downstream raw materials:

2-<3-<(benzyloxycarbonyl)amino>-2-oxo-5-phenyl-1,2-dihydro-1-pyridyl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropyl)acetamide