Technology Process of Carbamic acid,
[1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl
ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-5-iodo-2-oxo-3-pyridinyl]-,
phenylmethyl ester
There total 8 articles about Carbamic acid,
[1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl
ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-5-iodo-2-oxo-3-pyridinyl]-,
phenylmethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 98 percent / H2 / 10percent Pd/C / ethanol / 8 h / 760 Torr / Ambient temperature
2: 63 percent / Na2CO3 / tetrahydrofuran
3: 46 percent / N-iodosuccinimide / CH2Cl2 / 18 h
4: 1.) NaH / 1.) DMF, 15-25 deg C, 20 min, 2.) DMF, RT, 3 h
With
N-iodo-succinimide; hydrogen; sodium hydride; sodium carbonate;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00045a014
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 2,6-lutidine / 12 h
2: 92 percent / NaI / acetone / 18 h
3: 1.) NaH / 1.) DMF, 15-25 deg C, 20 min, 2.) DMF, RT, 3 h
With
2,6-dimethylpyridine; sodium hydride; sodium iodide;
In
acetone;
DOI:10.1021/jm00045a014
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 4-methylmorpholine / tetrahydrofuran / 18 h
2: 2,6-lutidine / 12 h
3: 92 percent / NaI / acetone / 18 h
4: 1.) NaH / 1.) DMF, 15-25 deg C, 20 min, 2.) DMF, RT, 3 h
With
4-methyl-morpholine; 2,6-dimethylpyridine; sodium hydride; sodium iodide;
In
tetrahydrofuran; acetone;
DOI:10.1021/jm00045a014
