Carbamic acid, [1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-5-iodo-2-oxo-3-pyridinyl]-, phenylmethyl ester

Base Information

Chemical Name:Carbamic acid, [1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-5-iodo-2-oxo-3-pyridinyl]-, phenylmethyl ester
CAS No.:147269-73-6
Molecular Formula:C27H37F3IN3O5Si
Molecular Weight:695.593
Hs Code.:

Carbamic acid,
[1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl
ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-5-iodo-2-oxo-3-pyridinyl]-,
phenylmethyl ester

Synonyms:

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Chemical Property of Carbamic acid, [1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-5-iodo-2-oxo-3-pyridinyl]-, phenylmethyl ester

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Safty Information:

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Technology Process of Carbamic acid, [1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-5-iodo-2-oxo-3-pyridinyl]-, phenylmethyl ester

There total 8 articles about Carbamic acid, [1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-5-iodo-2-oxo-3-pyridinyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6332-56-5
3-nitropyridone

: 147269-73-6
(1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-5-iodo-2-oxo-1,2-dihydro-pyridin-3-yl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / H₂ / 10percent Pd/C / ethanol / 8 h / 760 Torr / Ambient temperature

2: 63 percent / Na₂CO₃ / tetrahydrofuran

3: 46 percent / N-iodosuccinimide / CH₂Cl₂ / 18 h

4: 1.) NaH / 1.) DMF, 15-25 deg C, 20 min, 2.) DMF, RT, 3 h

With N-iodo-succinimide; hydrogen; sodium hydride; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00045a014

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 147269-73-6
(1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-5-iodo-2-oxo-1,2-dihydro-pyridin-3-yl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-lutidine / 12 h

2: 92 percent / NaI / acetone / 18 h

3: 1.) NaH / 1.) DMF, 15-25 deg C, 20 min, 2.) DMF, RT, 3 h

With 2,6-dimethylpyridine; sodium hydride; sodium iodide; In acetone;
DOI:10.1021/jm00045a014

Reference yield:

: 106746-09-2
3(RS)-amino-1,1,1-trifluoro-2(RS)-hydroxy-4-methylpentane hydrochloride

: 147269-73-6
(1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-5-iodo-2-oxo-1,2-dihydro-pyridin-3-yl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methylmorpholine / tetrahydrofuran / 18 h

2: 2,6-lutidine / 12 h

3: 92 percent / NaI / acetone / 18 h

4: 1.) NaH / 1.) DMF, 15-25 deg C, 20 min, 2.) DMF, RT, 3 h

With 4-methyl-morpholine; 2,6-dimethylpyridine; sodium hydride; sodium iodide; In tetrahydrofuran; acetone;
DOI:10.1021/jm00045a014