3-Amino-N-Boc-9-azabicyclo[3.3.1]nonane

Base Information

• Chemical Name: 3-Amino-N-Boc-9-azabicyclo[3.3.1]nonane
• CAS No.: 202797-03-3
• Molecular Formula: C13H24N2O2
• Molecular Weight: 240.34
• Mol file: 202797-03-3.mol

Synonyms:9-Azabicyclo[3.3.1]nonane-9-carboxylic acid, 3-amino-, 1,1-dimethylethyl ester;

Chemical Property of 3-Amino-N-Boc-9-azabicyclo[3.3.1]nonane

Chemical Property:

• Vapor Pressure: 0.000159mmHg at 25°C
• Refractive Index: 1.502
• Boiling Point: 331.1 °C at 760 mmHg
• Flash Point: 154 °C
• PSA: 55.56000
• Density: 1.061 g/cm³
• LogP: 2.90390

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Amino-N-Boc-9-azabicyclo[3.3.1]nonane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Amino-N-Boc-9-azabicyclo[3.3.1]nonane

There total 2 articles about 3-Amino-N-Boc-9-azabicyclo[3.3.1]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(1R,5S,E)-tert-butyl 3-(hydroxyimino)-9-azabicyclo[3.3.1]nonane-9-carboxylate → tert-butyl (1R,5S)-3-amino-9-azabicyclo[3.3.1]nonane-9-carboxylate (1887167-87-4,202797-03-3,1363380-67-9)

Guidance literature:

With hydrogen; In methanol; at 20 ℃; for 7h; under 1520.1 Torr;

Reference yield:

(1R,5S)-tert-butyl 3-oxo-9-azabicyclo[3.3.1]nonane-9-carboxylate → tert-butyl (1R,5S)-3-amino-9-azabicyclo[3.3.1]nonane-9-carboxylate (1887167-87-4,202797-03-3,1363380-67-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; hydroxylamine hydrochloride / ethanol; water / 8 h / 20 - 95 °C / Inert atmosphere

2: hydrogen / methanol / 7 h / 20 °C / 1520.1 Torr

With hydroxylamine hydrochloride; hydrogen; sodium hydroxide; In methanol; ethanol; water;

Reference yield: 88.0%

tert-butyl 3-amino-9-azabicyclo[3.3.1]nonane-9-carboxylate (1887167-87-4,202797-03-3,1363380-67-9) + 8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carbonyl chloride hydrochloride (1415502-89-4) + trifluoroacetic acid (76-05-1) → tert-butyl 3-[({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-9-azabicyclo[3.3.1]nonane-9-carboxylate trifluoroacetate

Guidance literature:

tert-butyl 3-amino-9-azabicyclo[3.3.1]nonane-9-carboxylate; 8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carbonyl chloride hydrochloride; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 1h;

trifluoroacetic acid; In water; acetonitrile;

Downstream raw materials:

(endo)-3-amino-9-methyl-9-azabicyclo[3.3.1]-nonane

Refernces