1H-Benzimidazole-7-carboxamide, 2-(1-propyl-4-piperidinyl)-

Base Information

Chemical Name:1H-Benzimidazole-7-carboxamide, 2-(1-propyl-4-piperidinyl)-
CAS No.:272769-49-0
Molecular Formula:C16H22N4O
Molecular Weight:286.37
Hs Code.:2934999090
NSC Number:733606
UNII:01FPW436S6
DSSTox Substance ID:DTXSID40181726
Nikkaji Number:J3.234.090C
Wikidata:Q27096558
Pharos Ligand ID:AMS1NSKB8WQ1
Metabolomics Workbench ID:150511
ChEMBL ID:CHEMBL452800
Mol file:272769-49-0.mol

Synonyms:2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide

Suppliers and Price of 1H-Benzimidazole-7-carboxamide, 2-(1-propyl-4-piperidinyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
2-(1-Propyl-4-piperidinyl)-1H-benzimidazole-7-carboxamide
10 mg
$ 650.00

Crysdot
2-(1-Propylpiperidin-4-yl)-1H-benzo[d]imidazole-7-carboxamide 95+%
1g
$ 780.00

Chemenu
2-(1-propylpiperidin-4-yl)-1H-benzo[d]imidazole-7-carboxamide 95%
1g
$ 729.00

American Custom Chemicals Corporation
2-(1-PROPYLPIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-4-CARBOXAMIDE 95.00%
5MG
$ 496.31

Alichem
2-(1-Propylpiperidin-4-yl)-1H-benzo[d]imidazole-7-carboxamide
1g
$ 690.80

Total 16 raw suppliers

Chemical Property of 1H-Benzimidazole-7-carboxamide, 2-(1-propyl-4-piperidinyl)-

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:573.215°C at 760 mmHg
PKA:17.82±0.30(Predicted)
Flash Point:300.47°C
PSA：75.01000
Density:1.193g/cm³
LogP:2.88940
XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:286.17936134
Heavy Atom Count:21
Complexity:367

Purity/Quality:

98%min ^*data from raw suppliers

2-(1-Propyl-4-piperidinyl)-1H-benzimidazole-7-carboxamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCN1CCC(CC1)C2=NC3=C(C=CC=C3N2)C(=O)N

Technology Process of 1H-Benzimidazole-7-carboxamide, 2-(1-propyl-4-piperidinyl)-

There total 13 articles about 1H-Benzimidazole-7-carboxamide, 2-(1-propyl-4-piperidinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: C₁₆H₂₄N₄O₂*ClH

: 272769-49-0
2-(1-propyl-4-piperidinyl)-1H-benzimidazole-4-carboxamide

Guidance literature:: With acetic acid; In water; for 4h; Inert atmosphere; Reflux; Large scale;
DOI:10.1021/op7000194

Reference yield:

: 603-11-2
3-nitrophthalic acid

: 272769-49-0
2-(1-propyl-4-piperidinyl)-1H-benzimidazole-4-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: acetic anhydride / Isopropyl acetate / 60 °C / Inert atmosphere; Large scale

2.1: ammonium hydroxide / 2.5 h / 0 - 15 °C / Inert atmosphere; Large scale

2.2: 20 °C / Inert atmosphere; Large scale

3.1: potassium hydroxide; potassium bromide; potassium hypobromite / water / 75 °C

4.1: thionyl chloride / 1,2-dimethoxyethane / 12 h / 50 °C / Large scale

5.1: ammonium hydroxide / 40 °C / Large scale

6.1: hydrogen / water; ethanol; ethyl acetate / 1.67 h / 40 °C / 2828.7 Torr / Cooling; Large scale

7.1: hydrogenchloride / ethyl acetate / 30 °C / Cooling; Large scale

8.1: 1-methyl-pyrrolidin-2-one / 30 - 50 °C / Large scale

9.1: acetic acid / water / 4 h / Inert atmosphere; Reflux; Large scale

With hydrogenchloride; ammonium hydroxide; thionyl chloride; potassium hypobromite; hydrogen; acetic anhydride; acetic acid; potassium bromide; potassium hydroxide; In 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; ethanol; Isopropyl acetate; water; ethyl acetate;
DOI:10.1021/op7000194

Reference yield:

: 641-70-3
3-nitrophthalic acid anhydride

: 272769-49-0
2-(1-propyl-4-piperidinyl)-1H-benzimidazole-4-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: ammonium hydroxide / 2.5 h / 0 - 15 °C / Inert atmosphere; Large scale

1.2: 20 °C / Inert atmosphere; Large scale

2.1: potassium hydroxide; bromine / water / 1.5 h / 0 - 75 °C / Inert atmosphere; Large scale

3.1: thionyl chloride / 1,2-dimethoxyethane / 12 h / 50 °C / Large scale

4.1: ammonium hydroxide / 40 °C / Large scale

5.1: hydrogen / water; ethanol; ethyl acetate / 1.67 h / 40 °C / 2828.7 Torr / Cooling; Large scale

6.1: hydrogenchloride / ethyl acetate / 30 °C / Cooling; Large scale

7.1: 1-methyl-pyrrolidin-2-one / 30 - 50 °C / Large scale

8.1: acetic acid / water / 4 h / Inert atmosphere; Reflux; Large scale

With hydrogenchloride; ammonium hydroxide; thionyl chloride; hydrogen; bromine; acetic acid; potassium hydroxide; In 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; ethanol; water; ethyl acetate; 2.1: |Hofmann Rearrangement;
DOI:10.1021/op7000194