[(S)-1-(CYCLOPROPYLCARBAMOYL-HYDROXY-METHYL)-BUTYL]-CARBAMIC ACID BENZYL ESTER

Base Information

Chemical Name:[(S)-1-(CYCLOPROPYLCARBAMOYL-HYDROXY-METHYL)-BUTYL]-CARBAMIC ACID BENZYL ESTER
CAS No.:402959-34-6
Molecular Formula:C17H24N2O4
Molecular Weight:320.389
Hs Code.:2924299090
Mol file:402959-34-6.mol

Synonyms:(S)-3-(benzyloxycarbonyl)amino-2-hydroxyhexanoylcyclopropylamide;BENZYL (3S)-1-(CYCLOPROPYLAMINO)-2-HYDROXY-1-OXOHEXAN-3-YLCARBAMATE;benzyl ((2S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl)carbamate;[(S)-1-(CYCLOPROPYLCARBAMOYL-HYDROXY-METHYL)-BUTYL]-CARBAMIC ACID BENZYL ESTER;N-[(1S)-1-[2-(Cyclopropylamino)-1-hydroxy-2-oxoethyl]butyl]carbamic Acid Benzyl Ester;Carbamic acid, N-[(1S)-1-[2-(cyclopropylamino)-1-hydroxy-2-oxoethyl]butyl]-, phenylmethyl ester

Suppliers and Price of [(S)-1-(CYCLOPROPYLCARBAMOYL-HYDROXY-METHYL)-BUTYL]-CARBAMIC ACID BENZYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-[(1S)-1-[2-(Cyclopropylamino)-1-hydroxy-2-oxoethyl]butyl]carbamicAcidBenzylEster
100mg
$ 1100.00

Medical Isotopes, Inc.
N-[(1S)-1-[2-(Cyclopropylamino)-1-hydroxy-2-oxoethyl]butyl]carbamicAcidBenzylEster
100 mg
$ 2000.00

Medical Isotopes, Inc.
N-[(1S)-1-[2-(Cyclopropylamino)-1-hydroxy-2-oxoethyl]butyl]carbamicAcidBenzylEster
10 mg
$ 625.00

American Custom Chemicals Corporation
BENZYL-(3S)-1-(CYCLOPROPYLAMINO)-2-HYDROXY-1-OXOHEXAN-3-YLCARBAMATE 95.00%
5MG
$ 496.00

Total 15 raw suppliers

Chemical Property of [(S)-1-(CYCLOPROPYLCARBAMOYL-HYDROXY-METHYL)-BUTYL]-CARBAMIC ACID BENZYL ESTER

Chemical Property:

Boiling Point:568.5±50.0 °C(Predicted)
PKA:11?+-.0.46(Predicted)
PSA：87.66000
Density:1.20±0.1 g/cm3(Predicted)
LogP:2.50280
Solubility.:Methanol

Purity/Quality:

99% ^*data from raw suppliers

N-[(1S)-1-[2-(Cyclopropylamino)-1-hydroxy-2-oxoethyl]butyl]carbamicAcidBenzylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses N-[(1S)-1-[2-(CyclopropylaMino)-1-hydroxy-2-oxoethyl]butyl]carbaMic Acid Benzyl Ester is used in the preparation of peptides for treatment of hepatitis C virus.

Technology Process of [(S)-1-(CYCLOPROPYLCARBAMOYL-HYDROXY-METHYL)-BUTYL]-CARBAMIC ACID BENZYL ESTER

There total 7 articles about [(S)-1-(CYCLOPROPYLCARBAMOYL-HYDROXY-METHYL)-BUTYL]-CARBAMIC ACID BENZYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 928064-71-5
methyl (S)-3-(benzyloxycarbonyl)amino-2-hydroxyhexanoate

: 765-30-0
Cyclopropylamine

: 402959-34-6
(S)-3-(benzyloxycarbonyl)amino-2-hydroxyhexanoylcyclopropylamide

Guidance literature:: In methanol; at 70 ℃; for 48h;

Reference yield:

: 765-30-0
Cyclopropylamine

: (S)-3-(benzyloxycarbonyl)amino-2-hydroxyhexanoic acid

: 402959-34-6
(S)-3-(benzyloxycarbonyl)amino-2-hydroxyhexanoylcyclopropylamide

Guidance literature:: (S)-3-(benzyloxycarbonyl)amino-2-hydroxyhexanoic acid; With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at -9.8 - 20 ℃; for 3h; Cooling with acetone-dry ice;

Cyclopropylamine; In N,N-dimethyl-formamide; at -10 - 20 ℃;

Reference yield:

: 6600-40-4,498-18-0
L-Norvaline

: 402959-34-6
(S)-3-(benzyloxycarbonyl)amino-2-hydroxyhexanoylcyclopropylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 6 h / Reflux; Inert atmosphere

2.1: potassium carbonate / water; tetrahydrofuran / 4 h / 20 °C

2.2: 2 h / 10 - 25 °C

3.1: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / toluene; dimethyl sulfoxide / 1 h / 0 °C / Inert atmosphere

3.2: 1 h / 0 °C

4.1: water; sodium dithionite / methanol / 0 °C / Cooling

4.2: 2 h / 25 °C

5.1: hydrogenchloride; water / 3 h / Reflux

5.2: Reflux

5.3: 3 h / 10 - 20 °C

6.1: methanol / 48 h / 70 °C

With hydrogenchloride; sodium dithionite; water; sulfur trioxide pyridine complex; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; toluene;