trans-3-Aminocyclobutanecarboxylic acid ethyl ester hydrochloride

Base Information

Chemical Name:trans-3-Aminocyclobutanecarboxylic acid ethyl ester hydrochloride
CAS No.:957793-36-1
Molecular Formula:C7H13NO2.HCl
Molecular Weight:179.647
Hs Code.:
Mol file:957793-36-1.mol

Synonyms:cyclobuta;Ethyl tra;LogP

Suppliers and Price of trans-3-Aminocyclobutanecarboxylic acid ethyl ester hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 22 raw suppliers

Chemical Property of trans-3-Aminocyclobutanecarboxylic acid ethyl ester hydrochloride

Chemical Property:

PSA：52.32000
LogP:1.78910

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of trans-3-Aminocyclobutanecarboxylic acid ethyl ester hydrochloride

There total 7 articles about trans-3-Aminocyclobutanecarboxylic acid ethyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: ethyl trans-3-azidocyclobutane-1-carboxylate

: 957793-36-1
ethyl trans-3-aminocyclobutane-1-carboxylate hydrochloride

Guidance literature:: ethyl trans-3-azidocyclobutane-1-carboxylate; With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 4h; under 2585.81 Torr;

With hydrogenchloride; In 1,4-dioxane;

Reference yield:

: 64-17-5
ethanol

: 84182-60-5
hydrochloride of trans-3-aminocyclobutane-1-carboxylic acid

: 957793-36-1
ethyl trans-3-aminocyclobutane-1-carboxylate hydrochloride

Guidance literature:: With thionyl chloride; at 0 - 100 ℃; for 16h;

Reference yield:

: 160351-97-3
ethyl (1S,3S)-3-hydroxycyclobutane-1-carboxylate

: 957793-36-1
ethyl trans-3-aminocyclobutane-1-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 20 °C

2: sodium azide / N,N-dimethyl-formamide / 16 h / 90 °C

3: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 20 °C / 2585.81 Torr

With sodium azide; palladium 10% on activated carbon; hydrogen; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;