8-{4-[3,6-Dioxo-5-[1-{4-[(thiophene-2-carbonyl)-amino]-phenyl}-meth-(Z)-ylidene]-piperazin-(2Z)-ylidenemethyl]-phenoxy}-octanoic acid methyl ester

Base Information

• Chemical Name: 8-{4-[3,6-Dioxo-5-[1-{4-[(thiophene-2-carbonyl)-amino]-phenyl}-meth-(Z)-ylidene]-piperazin-(2Z)-ylidenemethyl]-phenoxy}-octanoic acid methyl ester
• CAS No.: 386212-70-0
• Molecular Formula: C₃₂H₃₃N₃O₆S
• Molecular Weight: 587.697
• Mol file: 386212-70-0.mol

Synonyms:

Chemical Property of 8-{4-[3,6-Dioxo-5-[1-{4-[(thiophene-2-carbonyl)-amino]-phenyl}-meth-(Z)-ylidene]-piperazin-(2Z)-ylidenemethyl]-phenoxy}-octanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-{4-[3,6-Dioxo-5-[1-{4-[(thiophene-2-carbonyl)-amino]-phenyl}-meth-(Z)-ylidene]-piperazin-(2Z)-ylidenemethyl]-phenoxy}-octanoic acid methyl ester

There total 7 articles about 8-{4-[3,6-Dioxo-5-[1-{4-[(thiophene-2-carbonyl)-amino]-phenyl}-meth-(Z)-ylidene]-piperazin-(2Z)-ylidenemethyl]-phenoxy}-octanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-nitrophenyl)-1,3-dioxolane (2403-53-4) → 8-{4-[3,6-Dioxo-5-[1-{4-[(thiophene-2-carbonyl)-amino]-phenyl}-meth-(Z)-ylidene]-piperazin-(2Z)-ylidenemethyl]-phenoxy}-octanoic acid methyl ester (386212-70-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 100 percent / H₂ / PtO₂ / tetrahydrofuran

2.1: Et₃N / tetrahydrofuran

2.2: 85 percent / H⁺ / tetrahydrofuran

3.1: t-BuOK / 2-methyl-propan-2-ol; tetrahydrofuran / 20 °C

4.1: Cs₂CO₃ / dimethylformamide / 80 - 100 °C

With potassium tert-butylate; hydrogen; caesium carbonate; triethylamine; platinum(IV) oxide; In tetrahydrofuran; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/S0960-894X(01)00508-X

Reference yield:

4-nitrobenzaldehdye (555-16-8) → 8-{4-[3,6-Dioxo-5-[1-{4-[(thiophene-2-carbonyl)-amino]-phenyl}-meth-(Z)-ylidene]-piperazin-(2Z)-ylidenemethyl]-phenoxy}-octanoic acid methyl ester (386212-70-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 98 percent / pTSA / toluene / 2 h / Heating

2.1: 100 percent / H₂ / PtO₂ / tetrahydrofuran

3.1: Et₃N / tetrahydrofuran

3.2: 85 percent / H⁺ / tetrahydrofuran

4.1: t-BuOK / 2-methyl-propan-2-ol; tetrahydrofuran / 20 °C

5.1: Cs₂CO₃ / dimethylformamide / 80 - 100 °C

With potassium tert-butylate; hydrogen; caesium carbonate; toluene-4-sulfonic acid; triethylamine; platinum(IV) oxide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

DOI:10.1016/S0960-894X(01)00508-X

Reference yield:

methyl 8-(4-formylphenoxy)octanoate (386212-62-0) + Thiophene-2-carboxylic acid {4-[4-acetyl-3,6-dioxo-piperazin-(2Z)-ylidenemethyl]-phenyl}-amide → 8-{4-[3,6-Dioxo-5-[1-{4-[(thiophene-2-carbonyl)-amino]-phenyl}-meth-(Z)-ylidene]-piperazin-(2Z)-ylidenemethyl]-phenoxy}-octanoic acid methyl ester (386212-70-0)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 80 - 100 ℃;

DOI:10.1016/S0960-894X(01)00508-X

upstream raw materials:

methyl 8-(4-formylphenoxy)octanoate

4-(1,3-dioxolan-2-yl)aniline

methyl 8-bromooctanoate

2-(4-nitrophenyl)-1,3-dioxolane

Downstream raw materials:

8-{4-[3,6-Dioxo-5-[1-{4-[(thiophene-2-carbonyl)-amino]-phenyl}-meth-(Z)-ylidene]-piperazin-(2Z)-ylidenemethyl]-phenoxy}-octanoic acid