Chemical Property of (E)-N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine
Chemical Property:
- Boiling Point:535 °C at 760 mmHg
- Flash Point:277.4 °C
- PSA：76.20000
- Density:1.267 g/cm3
- LogP:2.59870
- Solubility.:insoluble in H2O; ≥18.75 mg/mL in DMSO; ≥2.55 mg/mL in EtOH with ultrasonic
- XLogP3:3.7
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:5
- Exact Mass:375.21714383
- Heavy Atom Count:28
- Complexity:499
- Purity/Quality:
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99%, *data from raw suppliers
(E)-N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine 97% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1=CC(=NN1)NC2=CC(=NC(=N2)C=CC3=CC=CC=C3)N4CCN(CC4)C
- Isomeric SMILES:CC1=CC(=NN1)NC2=CC(=NC(=N2)/C=C/C3=CC=CC=C3)N4CCN(CC4)C
- Recent ClinicalTrials:Study of ENMD-2076 in Patients With Advanced/Metastatic Soft Tissue Sarcoma
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Description
ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα. Phase 2.
