FLT3 inhibitors
FLT3 inhibitors are a class of compounds designed to target and block the activity of the FMS-like tyrosine kinase 3 (FLT3) receptor. FLT3 is a receptor tyrosine kinase that plays a critical role in regulating cell proliferation and survival, particularly in hematopoietic stem and progenitor cells. Mutations in FLT3, particularly internal tandem duplications (ITD) in the juxtamembrane domain or point mutations in the tyrosine kinase domain, are frequently found in acute myeloid leukemia (AML) and are associated with poor prognosis. FLT3 inhibitors work by binding to the ATP-binding site of the FLT3 kinase domain, thereby inhibiting its enzymatic activity and downstream signaling pathways involved in cell proliferation and survival. By blocking FLT3 signaling, these inhibitors aim to induce apoptosis (programmed cell death) in leukemic cells harboring FLT3 mutations and to inhibit the growth and progression of AML.
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