Rucaparib phosphate

Base Information

Chemical Name:Rucaparib phosphate
CAS No.:459868-92-9
Molecular Formula:C19H18FN3O.H3O4P
Molecular Weight:421.36
Hs Code.:
European Community (EC) Number:813-337-0
UNII:H3M9955244
Wikidata:Q27279598
NCI Thesaurus Code:C78186
ChEMBL ID:CHEMBL2105733
Mol file:459868-92-9.mol

Synonyms:AG 014699;AG-014699;AG014699;PF-01367338;Rubraca;rucaparib

Suppliers and Price of Rucaparib phosphate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
AG14699
5mg
$ 90.00

TRC
AG14699
10mg
$ 140.00

Medical Isotopes, Inc.
AG14699
5 mg
$ 290.00

Matrix Scientific
8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one phosphate 95%
1g
$ 565.00

Matrix Scientific
8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one phosphate 95%
5g
$ 1465.00

DC Chemicals
Rucaparibphosphate(AG-14699,PF-01367338) >98%
1 g
$ 1350.00

DC Chemicals
Rucaparibphosphate(AG-14699,PF-01367338) >98%
250 mg
$ 650.00

DC Chemicals
Rucaparibphosphate(AG-14699,PF-01367338) >98%
100 mg
$ 350.00

CSNpharm
RucaparibPhosphate
100mg
$ 398.00

Crysdot
Rucaparibphosphate 98+%
100mg
$ 636.00

Total 88 raw suppliers

Chemical Property of Rucaparib phosphate

Chemical Property:

Vapor Pressure:1.5E-15mmHg at 25°C
Boiling Point:625.2 °C at 760 mmHg
Flash Point:331.9 °C
PSA：144.49000
LogP:2.77040
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:Soluble in DMSO (up to 25 mg/ml).
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:421.12028594
Heavy Atom Count:29
Complexity:515

Purity/Quality:

99% ^*data from raw suppliers

AG14699 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=C3C(=CC(=C4)F)N2.OP(=O)(O)O
Recent ClinicalTrials:A Study Of Poly (ADP-Ribose) Polymerase Inhibitor PF-01367338 In Combination With Several Chemotherapeutic Regimens
Recent EU Clinical Trials:Window study of the PARP inhibitor rucaparib in patients with primary triple negative or BRCA1/2 related breast cancer (RIO)
Description Rucaparib phosphate (459868-92-9) is a potent (Ki<5 nM) PARP1 inhibitor.1?Cytotoxic to human cancer cells or xenograft tumors with mutated or epigenetically silenced BRCA1/2.2?Demonstrates antiproliferative effects in 26 out of 39 ovarian cancer cell lines.3?Synergizes with other anticancer agents such as topotecan, carboplatin, doxorubicin, paclitaxel,3 and temozolomide.4?Ameliorates the cardiotoxicity of doxorubicin.5?Recently approved for human use by the FDA.
Uses PARP inhibitor oncolytic

Technology Process of Rucaparib phosphate

There total 1 articles about Rucaparib phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%