ethyl 4-(chloroMethyl)-2-phenylthiazole-5-carboxylate

Base Information

• Chemical Name: ethyl 4-(chloroMethyl)-2-phenylthiazole-5-carboxylate
• CAS No.: 83983-12-4
• Molecular Formula: C13H12ClNO2S
• Molecular Weight: 281.76
• Mol file: 83983-12-4.mol

Synonyms:4-Chlormethyl-5-ethoxycarbonyl-2-phenyl-thiazol;ethyl 4-(chloroMethyl)-2-phenylthiazole-5-carboxylate;4-(Chloromethyl)-2-phenyl-5-thiazolecarboxylic acid ethyl ester;5-Thiazolecarboxylic acid, 4-(chloromethyl)-2-phenyl-, ethyl ester

Chemical Property of ethyl 4-(chloroMethyl)-2-phenylthiazole-5-carboxylate

Chemical Property:

• Melting Point: 110 °C(Solv: ethanol (64-17-5))
• Boiling Point: 442.0±55.0 °C(Predicted)
• PKA: -1.24±0.10(Predicted)
• PSA: 67.43000
• Density: 1.283±0.06 g/cm3(Predicted)
• LogP: 3.72560

Purity/Quality:

99% ^*data from raw suppliers

Ethyl4-(chloromethyl)-2-phenylthiazole-5-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 4-(chloroMethyl)-2-phenylthiazole-5-carboxylate

There total 2 articles about ethyl 4-(chloroMethyl)-2-phenylthiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Phenyl-4-chlormethyl-thiazol-5-yl-carbonsaeure (41980-85-2) → 4-Chlormethyl-5-ethoxycarbonyl-2-phenyl-thiazol (83983-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 1 h / Heating

2: 0.08 h / Heating

With thionyl chloride;

DOI:10.1002/ardp.19833161208

Reference yield:

ethanol (64-17-5) + 5-Chlorformyl-4-chlormethyl-2-phenyl-thiazol (88469-68-5) → 4-Chlormethyl-5-ethoxycarbonyl-2-phenyl-thiazol (83983-12-4)

Guidance literature:

for 0.0833333h; Heating;

DOI:10.1002/ardp.19833161208

Reference yield:

4-Chlormethyl-5-ethoxycarbonyl-2-phenyl-thiazol (83983-12-4) → 7-chloro-2-phenylthiazolo<4,5-d>pyridazine (88469-76-5)

Guidance literature:

Multi-step reaction with 5 steps

1: water / 4 h / Heating

2: conc. H₂SO₄ / Heating

3: K₂Cr₂O₇ / acetic acid / 1 h

4: N₂H₄*H₂O / aq. ethanol / 6 h / Heating

5: POCl₃ / Heating

With potassium dichromate; sulfuric acid; water; hydrazine hydrate; trichlorophosphate; In ethanol; acetic acid;

DOI:10.1002/ardp.19833161208

upstream raw materials:

ethanol

5-Chlorformyl-4-chlormethyl-2-phenyl-thiazol

2-Phenyl-4-chlormethyl-thiazol-5-yl-carbonsaeure

Downstream raw materials:

5-Carboxy-4-hydroxymethyl-2-phenyl-thiazol

ethyl 4-(hydroxymethyl)-2-phenyl-1,3-thiazole-5-carboxylate

5-Carbocy-4-formyl-2-phenyl-thiazol

7-chloro-2-phenylthiazolo<4,5-d>pyridazine