5-amino-N'-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-1',3'-diphenyl-2,3-dihydro-1H,1'H-3,4'-bipyrazole-4-carbohydrazide

Base Information

• Chemical Name: 5-amino-N'-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-1',3'-diphenyl-2,3-dihydro-1H,1'H-3,4'-bipyrazole-4-carbohydrazide
• CAS No.: 1431861-24-3
• Molecular Formula: C₂₇H₂₂N₈O₂
• Molecular Weight: 490.524
• Mol file: 1431861-24-3.mol

Synonyms:

Chemical Property of 5-amino-N'-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-1',3'-diphenyl-2,3-dihydro-1H,1'H-3,4'-bipyrazole-4-carbohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-amino-N'-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-1',3'-diphenyl-2,3-dihydro-1H,1'H-3,4'-bipyrazole-4-carbohydrazide

There total 3 articles about 5-amino-N'-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-1',3'-diphenyl-2,3-dihydro-1H,1'H-3,4'-bipyrazole-4-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

2-cyano-3-(1,3-diphenyl-1H-pyrazol-4-yl)-N'-[2-oxo-1,2-dihydro-3H-indol-3-ylidene]acrylohydrazide (1431861-47-0) → 5-amino-N'-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-1',3'-diphenyl-2,3-dihydro-1H,1'H-3,4'-bipyrazole-4-carbohydrazide (1431861-24-3)

Guidance literature:

With hydrazine hydrate; In butan-1-ol; for 3h; Reflux;

DOI:10.3184/174751912X13567100793191

Reference yield:

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → 5-amino-N'-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-1',3'-diphenyl-2,3-dihydro-1H,1'H-3,4'-bipyrazole-4-carbohydrazide (1431861-24-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,4-dioxane / 0.08 h / Reflux

2: potassium hydroxide / 1,4-dioxane; ethanol; water / 1 h / Reflux

3: hydrazine hydrate / butan-1-ol / 3 h / Reflux

With hydrazine hydrate; potassium hydroxide; In 1,4-dioxane; ethanol; water; butan-1-ol;

DOI:10.3184/174751912X13567100793191

Reference yield:

2-cyano-N'-(2-oxo-1,2-dihydroindol-3-ylidene)acetohydrazide (29775-72-2) → 5-amino-N'-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-1',3'-diphenyl-2,3-dihydro-1H,1'H-3,4'-bipyrazole-4-carbohydrazide (1431861-24-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / 1,4-dioxane; ethanol; water / 1 h / Reflux

2: hydrazine hydrate / butan-1-ol / 3 h / Reflux

With hydrazine hydrate; potassium hydroxide; In 1,4-dioxane; ethanol; water; butan-1-ol;

DOI:10.3184/174751912X13567100793191

upstream raw materials:

indole-2,3-dione

2-cyano-N'-(2-oxo-1,2-dihydroindol-3-ylidene)acetohydrazide

2-cyano-3-(1,3-diphenyl-1H-pyrazol-4-yl)-N'-[2-oxo-1,2-dihydro-3H-indol-3-ylidene]acrylohydrazide