1431861-47-0Relevant articles and documents
Synthesis and antioxidant screening of new 2-cyano-3-(1,3-diphenyl-1H-pyrazol-4-yl)acryloyl amide derivatives and some pyrazole-based heterocycles
El-Helw, Eman A. E.,Elgubbi, Amna S.,Sallam, Hanan A.
, (2020)
The high functionality compound namely 2-cyano-3-(1,3-diphenyl-1H-pyrazol-4-yl)acryloyl chloride (1) was utilized as a building block synthon via reactions with some nitrogen and sulfur nucleophilic reagents. The present work was planned to study the effect of 2-cyano group on the reactivity and stability of C2–C3 double bond toward different strong-to-weak nucleophiles, in addition to its facility of nucleophilic addition at C2–C3 double bond to construct new heterocyclic derivatives. The proclivity toward some mono-, 1,2-, 1,3-, 1,4-, and 1,5-binucleophiles was investigated. The reaction with 2-cyanoacetohydrazide was mainly dependent on the reaction conditions. Some new heterocycles integrated with pyrazole scaffold were successfully synthesized, such as benzoxazinone, indoline, isoindoline, pyrazolone, chromene, and pyrimidopyrimidine derivatives. Some of the newly synthesized compounds were screened for their antioxidant activity using ABTS method, and the results revealed that some compounds exhibited promising inhibitory antioxidant activity.
Utility of cyano-N-(2-oxo-1,2-dihydroindol-3-ylidene)acetohydrazide in the synthesis of novel heterocycles
Mahmoud, Mahmoud. R.,El-Ziaty, Ahmed. K.,Abu El-Azm, Fatma. S.M.,Ismail, Mahmoud F.,Shibab, Sayed. A.
, p. 80 - 85 (2013/04/23)
Cyano-N-(2-oxo-1,2-dihydroindol-3-ylidene)acetohydrazide was prepared by condensation of isatin with cyanoacetohydrazide in refluxing 1,4-dioxane. Subsequent reaction with a variety of electrophilic and nucleophilic reagents afforded novel heterocyclic compounds and spirooxoindoles. The IR, 1H NMR and mass spectra of all the synthesised compounds are discussed.
