2-(2-aMino-5-broMophenyl)-2-oxoacetic acid

Base Information

• Chemical Name: 2-(2-aMino-5-broMophenyl)-2-oxoacetic acid
• CAS No.: 17617-25-3
• Molecular Formula: C₈H₆BrNO₃
• Molecular Weight: 244.045
• Mol file: 17617-25-3.mol

Synonyms:

Chemical Property of 2-(2-aMino-5-broMophenyl)-2-oxoacetic acid

Chemical Property:

Purity/Quality:

2-(2-Amino-5-bromophenyl)-2-oxoaceticacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-aMino-5-broMophenyl)-2-oxoacetic acid

There total 2 articles about 2-(2-aMino-5-broMophenyl)-2-oxoacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Bromo-1H-indole-2,3-dione (87-48-9) → bromoisatic acid (17617-25-3)

Guidance literature:

5-Bromo-1H-indole-2,3-dione; With water; potassium hydroxide; at 20 ℃;

With hydrogenchloride; In water; pH=2 - 3;

DOI:10.3987/COM-12-12479

Reference yield:

2-ethoxy-5-bromo-indol-3-one → bromoisatic acid (17617-25-3)

Guidance literature:

geht erst in 5-Brom-isatin, dann in Produkt₁ ueber;

Reference yield:

bromoisatic acid (17617-25-3) → 5-bromo-1-methyl-3-oxoindazolin-2-yl(methoxycarbonyl)methylenetriphenylphosphorane (86670-76-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) HNO₂, 2.) NaOH / 2.) EtOH, 2-3 deg C

2: K₂CO₃ / methanol / Ambient temperature

With sodium hydroxide; cis-nitrous acid; potassium carbonate; In methanol;

DOI:10.1039/c39830000337

upstream raw materials:

5-Bromo-1H-indole-2,3-dione

Downstream raw materials:

5-bromo-3-oxoindazolin-2-yl(methoxycarbonyl)methylenetriphenylphosphorane

5-bromo-1-methyl-3-oxoindazolin-2-yl(methoxycarbonyl)methylenetriphenylphosphorane

Refernces

• 1、 Lv, Qinghua,Fang, Lizhen,Lu, Chenjuan,Wang, Pengfei. "Improved synthesis of 1-oxo-1,2,3,4-tetrahydroacridine-9-carboxylic acids from isatins and 1,3-cyclohexanedione". experimental part. p. 1457 - 1463. Retrieved 2012/08/07.