Ethyl 4-chloro-6-methyl-2-quinazolinecarboxylate

Base Information

• Chemical Name: Ethyl 4-chloro-6-methyl-2-quinazolinecarboxylate
• CAS No.: 620957-95-1
• Molecular Formula: C12H11ClN2O2
• Molecular Weight: 250.68094
• Hs Code.: 2933599590
• Mol file: 620957-95-1.mol

Synonyms:2-Quinazolinecarboxylic acid, 4-chloro-6-methyl-, ethyl ester;

Chemical Property of Ethyl 4-chloro-6-methyl-2-quinazolinecarboxylate

Chemical Property:

• Vapor Pressure: 8.89E-07mmHg at 25°C
• Refractive Index: 1.605
• Boiling Point: 405.3 °C at 760 mmHg
• PKA: -0.60±0.30(Predicted)
• Flash Point: 198.9 °C
• PSA: 52.08000
• Density: 1.301 g/cm³
• LogP: 2.76830

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 4-chloro-6-methyl-2-quinazolinecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 4-chloro-6-methyl-2-quinazolinecarboxylate

There total 3 articles about Ethyl 4-chloro-6-methyl-2-quinazolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

ethyl 6-methyl-4-oxo-3,4-dihydroquinazoline-2-carboxylate (869294-64-4) → ethyl 4-chloro-6-methylquinazoline-2-carboxylate (620957-95-1)

Guidance literature:

With N,N-dimethyl-aniline; trichlorophosphate; In toluene; at 130 ℃; for 2h;

DOI:10.1021/ml500497s

Reference yield:

ethyl 2-amino-5-methylbenzoate (58677-05-7) → ethyl 4-chloro-6-methylquinazoline-2-carboxylate (620957-95-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane / 0.08 h

1.2: 3 h / 20 - 100 °C

2.1: N,N-dimethyl-aniline; trichlorophosphate / toluene / 2 h / 130 °C

With hydrogenchloride; N,N-dimethyl-aniline; trichlorophosphate; In 1,4-dioxane; toluene;

DOI:10.1021/ml500497s

Reference yield:

2-Amino-5-methylbenzoic acid (2941-78-8) → ethyl 4-chloro-6-methylquinazoline-2-carboxylate (620957-95-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfuric acid / 72 h / 110 °C

2.1: hydrogenchloride / 1,4-dioxane / 0.08 h

2.2: 3 h / 20 - 100 °C

3.1: N,N-dimethyl-aniline; trichlorophosphate / toluene / 2 h / 130 °C

With hydrogenchloride; sulfuric acid; N,N-dimethyl-aniline; trichlorophosphate; In 1,4-dioxane; toluene;

DOI:10.1021/ml500497s

upstream raw materials:

ethyl 2-amino-5-methylbenzoate

ethyl 6-methyl-4-oxo-3,4-dihydroquinazoline-2-carboxylate

2-Amino-5-methylbenzoic acid

Downstream raw materials:

4-{[(1S,2R)-2-({(tert-butoxycarbonyl)amino[(tert-butoxycarbonyl)imino]methyl}amino)cyclohexyl]amino}-N-(4-methoxyphenyl)-6-methylquinazoline-2-carboxamide

4-{[(1S,2R)-2-({(tert-butoxycarbonyl)amino[(tert-butoxycarbonyl)imino]methyl}amino)cyclohexyl]amino}-N-isobutyl-6-methylquinazoline-2-carboxamide

4-{[(1S,2R)-2-({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)cyclohexyl]amino}-6-methylquinazoline-2-carboxylic acid ethyl ester

4-{[(1S,2R)-2-({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)cyclohexyl]amino}-6-methylquinazoline-2-carboxylic acid