58677-05-7

Basic information

• Product Name: ETHYL 2-AMINO-5-METHYLBENZOATE
• Synonyms: ETHYL 2-AMINO-5-METHYLBENZOATE;2-Amino-5-methylbenzoic acid ethyl ester
• CAS NO: 58677-05-7
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.21572
• Mol File: 58677-05-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 90-92 °C(Press: 0.08 Torr)
• Appearance: /
• Density: 1.103
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.52±0.10(Predicted)
• CAS DataBase Reference: ETHYL 2-AMINO-5-METHYLBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-AMINO-5-METHYLBENZOATE(58677-05-7)
• EPA Substance Registry System: ETHYL 2-AMINO-5-METHYLBENZOATE(58677-05-7)

Safety Data

• Hazardous Substances Data: 58677-05-7(Hazardous Substances Data)

Usage

General Description

ETHYL 2-AMINO-5-METHYLBENZOATE is a chemical compound with the molecular formula C10H13NO2. It is also known by the name Ethyl anthranilate and is commonly used in the fragrance and flavor industry due to its pleasant sweet, floral, and grape-like aroma. It is often used in the production of perfumes, soaps, and detergents. Additionally, it is used as a flavoring agent in foods and beverages. However, it is important to note that ethyl 2-amino-5-methylbenzoate may cause irritation to the skin, eyes, and respiratory system. Therefore, it is crucial to handle and use this chemical with proper precautionary measures.

Upstream product

• 54064-40-3 5-methyl-2-nitrobenzoic acid ethyl ester 
• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 64-17-5 ethanol 

Downstream Products

• 620957-95-1 ethyl 4-chloro-6-methylquinazoline-2-carboxylate 
• 1119086-11-1 2-(6-(3-methoxyphenyl)-5-methylpyridin-3-ylamino)-5-methylbenzoic acid 
• 320740-16-7 2-amino-3-iodo-5-methylbenzoic acid 
• 543740-77-8 ethyl 2-amino-3-iodo-5-methylbenzoate 
• 83494-90-0 2-amino-5-methyl-benzoic acid ethyl ester; thiocyanate 
• 106012-79-7 ethyl 2-isothiocyanato-5-methylbenzoate 
• 50440-82-9 2-amino-3,4-dihydro-6-methyl-4-oxoquinazoline 

Relevant articles and documents

Overcoming the Deallylation Problem: Palladium(II)-Catalyzed Chemo-, Regio-, and Stereoselective Allylic Oxidation of Aryl Allyl Ether, Amine, and Amino Acids

We report herein a Pd(II)/bis-sulfoxide-catalyzed intramolecular allylic C-H acetoxylation of aryl allyl ether, amine, and amino acids with the retention of a labile allyl moiety. Mechanistically, the reaction proceeds through a distinct double-bond isomerization from the allylic to the vinylic position followed by intramolecular carboxypalladation and the β-hydride elimination pathway. For the first time, C-H oxidation of N-allyl-protected amino acids to furnish five-membered heterocycles through 1,3-syn-addition is established with excellent diastereoselectivity.

Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives

Smoothened (Smo) is the signal transducer of the Hedgehog (Hh) pathway and its stimulation is considered a potential powerful tool in regenerative medicine to treat severe tissue injuries. Starting from GSA-10, a recently reported Hh activator acting on Smo, we have designed and synthesized a new class of quinolone-based compounds. Modification and decoration of three different portions of the original scaffold led to compounds able to induce differentiation of multipotent mesenchymal cells into osteoblasts. The submicromolar activity of several of these new quinolones (0.4–0.9?μM) is comparable to or better than that of SAG and purmorphamine, two reference Smo agonists. Structure-activity relationships allow identification of several molecular determinants important for the activity of these compounds.

Synthesis of symmetric diester-functionalised Troeger's base analogues

The yields of ester-functionalised Troeger's base analogues are dramatically improved by incorporating an electron-donating group on the aromatic ring and/or enhancing solubil- ity of the aniline unit. In addition to 2,8-diester compounds, 1,7-, 3,9- and 4,10-diester-functionalised Troeger's base analogues have been prepared for the first time.