58677-05-7

Usage

Uses

Used in Fragrance Industry:
ETHYL 2-AMINO-5-METHYLBENZOATE is used as a fragrance ingredient for its ability to impart a pleasant, sweet, floral scent to various products. It is particularly favored for its grape-like aroma, which adds depth and complexity to perfumes, soaps, and detergents.
Used in Flavor Industry:
In the flavor industry, ETHYL 2-AMINO-5-METHYLBENZOATE serves as a flavoring agent, enhancing the taste profiles of foods and beverages. Its sweet and fruity notes contribute to the overall flavor experience, making it suitable for a wide range of applications, from confectionery to beverages.
Used in Cosmetics and Personal Care Products:
ETHYL 2-AMINO-5-METHYLBENZOATE is also utilized in the formulation of cosmetics and personal care products, where it adds a desirable scent and contributes to the overall sensory experience of these products. Its use in these applications is due to its compatibility with various ingredients and its ability to provide a long-lasting aroma.
Used in Food and Beverage Industry:
As a flavoring agent in the food and beverage industry, ETHYL 2-AMINO-5-METHYLBENZOATE is employed to add a unique, sweet, and fruity taste to a variety of products. Its versatility allows it to be used in a range of applications, from enhancing the flavor of alcoholic beverages to adding a distinct taste to confectionery items.
Used in Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, ETHYL 2-AMINO-5-METHYLBENZOATE may also find use in the pharmaceutical industry, potentially serving as an active ingredient or excipient in the development of medications, given its chemical properties and the possibility of its interaction with biological systems. However, further research and regulatory approval would be required to confirm its suitability for such applications.

Upstream product

• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 64-17-5 ethanol 
• 54064-40-3 5-methyl-2-nitrobenzoic acid ethyl ester 

Downstream Products

• 106012-79-7 ethyl 2-isothiocyanato-5-methylbenzoate 
• 543740-77-8 ethyl 2-amino-3-iodo-5-methylbenzoate 
• 320740-16-7 2-amino-3-iodo-5-methylbenzoic acid 
• 1119086-11-1 2-(6-(3-methoxyphenyl)-5-methylpyridin-3-ylamino)-5-methylbenzoic acid 
• 620957-95-1 ethyl 4-chloro-6-methylquinazoline-2-carboxylate 
• 83494-90-0 2-amino-5-methyl-benzoic acid ethyl ester; thiocyanate 
• 50440-82-9 2-amino-3,4-dihydro-6-methyl-4-oxoquinazoline 

Relevant academic research and scientific papers

Overcoming the Deallylation Problem: Palladium(II)-Catalyzed Chemo-, Regio-, and Stereoselective Allylic Oxidation of Aryl Allyl Ether, Amine, and Amino Acids

We report herein a Pd(II)/bis-sulfoxide-catalyzed intramolecular allylic C-H acetoxylation of aryl allyl ether, amine, and amino acids with the retention of a labile allyl moiety. Mechanistically, the reaction proceeds through a distinct double-bond isomerization from the allylic to the vinylic position followed by intramolecular carboxypalladation and the β-hydride elimination pathway. For the first time, C-H oxidation of N-allyl-protected amino acids to furnish five-membered heterocycles through 1,3-syn-addition is established with excellent diastereoselectivity.

RE[N(SiMe3)2]3-Catalyzed Guanylation/Cyclization of Amino Acid Esters and Carbodiimides

The example of rare-earth metal-catalyzed guanylation/cyclization of amino acid esters and carbodiimides is well-established, forming 4(3H)-2-alkylaminoquinazolinones in 65-96% yields. The rare-earth metal amides RE[N(TMS)2]3 (RE = Y, Yb, Nd, Sm, La; TMS = SiMe3) showed high activities, and La[N(TMS)2]3 performed best for a wide scope of the substrates.

Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives

Smoothened (Smo) is the signal transducer of the Hedgehog (Hh) pathway and its stimulation is considered a potential powerful tool in regenerative medicine to treat severe tissue injuries. Starting from GSA-10, a recently reported Hh activator acting on Smo, we have designed and synthesized a new class of quinolone-based compounds. Modification and decoration of three different portions of the original scaffold led to compounds able to induce differentiation of multipotent mesenchymal cells into osteoblasts. The submicromolar activity of several of these new quinolones (0.4–0.9?μM) is comparable to or better than that of SAG and purmorphamine, two reference Smo agonists. Structure-activity relationships allow identification of several molecular determinants important for the activity of these compounds.

Synthesis and evaluation of quinazolines as inhibitors of the bacterial cell division protein FtsZ

The bacterial cell division protein FtsZ is one of many potential targets for the development of novel antibiotics. Recently, zantrin Z3 was shown to be a cross-species inhibitor of FtsZ; however, its specific interactions with the protein are still unknown. Herein we report the synthesis of analogues that contain a more tractable core structure and an analogue with single-digit micromolar inhibition of FtsZs GTPase activity, which represents the most potent inhibitor of Escherichia coli FtsZ reported to date. In addition, the zantrin Z3 core has been converted to two potential photo-cross-linking reagents for proteomic studies that could shed light on the molecular interactions between FtsZ and molecules related to zantrin Z3.

Synthesis of symmetric diester-functionalised Troeger's base analogues

The yields of ester-functionalised Troeger's base analogues are dramatically improved by incorporating an electron-donating group on the aromatic ring and/or enhancing solubil- ity of the aniline unit. In addition to 2,8-diester compounds, 1,7-, 3,9- and 4,10-diester-functionalised Troeger's base analogues have been prepared for the first time.

AZABIPHENYLAMINOBENZOIC ACID DERIVATIVES AS DHODH INHIBITORS

New azabiphenylaminobenzoic acid derivatives having the chemcial structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of the dehydroorotate dihydrogenase (DHODH)

Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives

The present invention is a compound of formula wherein R1 is halogen or lower alkyl; R2 is hydrogen, lower alkyl, cycloalkyl, —(CH2)m-phenyl, wherein the phenyl ring may be substituted by lower alkoxy, or is —(CH2)m-indolyl; R3 is —C(O)O-lower alkyl, —C(O)OH, or a five membered heteroaromatic group, which rings may be substituted by lower alkyl or cycloalkyl; n is 0, 1 or 2; m is 0, 1 or 2; or a pharmaceutically acceptable acid addition salt thereof. Compound I shows high affinity and selectivity for GALA A α5 receptor binding sites.

Investigation into a By-product from the Reaction of 2-Amino-5-methylbenzoic Acid with Ammonium Thiocyanate

One of the by-products from the reaction of 2-amino-5-methylbenzoic acid with ammonium thiocyanate is shown to be 2,3-dihydro-5-methyl-2-thioxo-3-p-tolylquinazolin-4(1H)-one (6).This reacts with hydrazine to give three products (21)-(23), which have been converted into tetrazolo- (27) and 1,2,4-triazolo-quinazolino-derivatives (20) and (30).The products from the reaction of o-aminoacetophenone with an aryl isothiocyanate are converted into a reactive 1-azabuta-1,3-diene intermediate (34), which undergoes a ? cycloaddition reaction with dimethyl acetylenedicarboxylate, followed by a retro-Diels-Alder reaction, to give dimethyl 4-methylquinoline-2,3-dicarboxylate.