7-Methoxyquinazoline

Base Information

• Chemical Name: 7-Methoxyquinazoline
• CAS No.: 10105-37-0
• Molecular Formula: C9H8N2O
• Molecular Weight: 160.1726
• Hs Code.: 2933990090
• European Community (EC) Number: 874-822-0
• ChEMBL ID: CHEMBL300491
• Nikkaji Number: J112.988K
• Pharos Ligand ID: CQX2UAL27PNB
• Mol file: 10105-37-0.mol

Synonyms:7-methoxyquinazoline;10105-37-0;7-Methoxy-quinazoline;CHEMBL300491;Quinazoline, 7-methoxy-;SCHEMBL668493;CHRMMMLUWHPZAH-UHFFFAOYSA-N;BDBM50049568;MFCD18378811;AKOS022189995;AS-40488;CS-0084770;EN300-124642;Z1255402381

Chemical Property of 7-Methoxyquinazoline

Chemical Property:

• Boiling Point: 287.141 °C at 760 mmHg
• Flash Point: 105.324 °C
• PSA: 35.01000
• Density: 1.195 g/cm³
• LogP: 1.63840
• Storage Temp.: 2-8°C
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 160.063662883
• Heavy Atom Count: 12
• Complexity: 152

Purity/Quality:

97% ^*data from raw suppliers

7-Methoxyquinazoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=NC=NC=C2C=C1

Technology Process of 7-Methoxyquinazoline

There total 5 articles about 7-Methoxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

hexamethylenetetramine (100-97-0) + ethyl N-(3-methoxyphenyl)carbamate (108708-80-1) → 7-Methoxy-chinazolin (10105-37-0)

Guidance literature:

hexamethylenetetramine; ethyl N-(3-methoxyphenyl)carbamate; With trifluoroacetic acid; for 1h; Heating;

With potassium hydroxide; potassium hexacyanoferrate(III); In ethanol; water; for 4h; Heating;

DOI:10.1016/j.tet.2006.09.103

Reference yield:

(OCH3)C8H6N2CO2C2H5 → 7-Methoxy-chinazolin (10105-37-0)

Guidance literature:

With potassium hydroxide; potassium hexacyanoferrate(III); In ethanol; water; at 100 ℃; for 0.5h; microwave irradiation;

DOI:10.1016/j.tetlet.2007.03.027

Reference yield:

ethyl N-(3-methoxyphenyl)carbamate (108708-80-1) → 7-Methoxy-chinazolin (10105-37-0)

Guidance literature:

Multi-step reaction with 2 steps

1: TFA / 0.17 h / 110 °C / microwave irradiation

2: K₃Fe(CN)6; KOH / H₂O; ethanol / 0.5 h / 100 °C / microwave irradiation

With potassium hydroxide; trifluoroacetic acid; potassium hexacyanoferrate(III); In ethanol; water;

DOI:10.1016/j.tetlet.2007.03.027

upstream raw materials:

hexamethylenetetramine

ethyl N-(3-methoxyphenyl)carbamate

m-Anisidine