(R)-2-Benzyloxycarbonylamino-3,3,3-trifluoro-2-[(R)-phenyl-((R)-toluene-4-sulfinyl)-methyl]-propionic acid methyl ester

Base Information

• Chemical Name: (R)-2-Benzyloxycarbonylamino-3,3,3-trifluoro-2-[(R)-phenyl-((R)-toluene-4-sulfinyl)-methyl]-propionic acid methyl ester
• CAS No.: 184636-34-8
• Molecular Formula: C₂₆H₂₄F₃NO₅S
• Molecular Weight: 519.541
• Mol file: 184636-34-8.mol

Synonyms:

Chemical Property of (R)-2-Benzyloxycarbonylamino-3,3,3-trifluoro-2-[(R)-phenyl-((R)-toluene-4-sulfinyl)-methyl]-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-Benzyloxycarbonylamino-3,3,3-trifluoro-2-[(R)-phenyl-((R)-toluene-4-sulfinyl)-methyl]-propionic acid methyl ester

There total 1 articles about (R)-2-Benzyloxycarbonylamino-3,3,3-trifluoro-2-[(R)-phenyl-((R)-toluene-4-sulfinyl)-methyl]-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

2-benzyloxycarbonylimino-3,3,3-trifluoropropionic acid methyl ester (128970-26-3) + (R)-1-(benzylsulfinyl)-4-methylbenzene (4820-08-0,10381-70-1,68680-65-9,4820-07-9) → (S)-2-Benzyloxycarbonylamino-3,3,3-trifluoro-2-[(R)-phenyl-((R)-toluene-4-sulfinyl)-methyl]-propionic acid methyl ester (184636-33-7) + (R)-2-Benzyloxycarbonylamino-3,3,3-trifluoro-2-[(R)-phenyl-((R)-toluene-4-sulfinyl)-methyl]-propionic acid methyl ester (184636-34-8) + (R)-2-Benzyloxycarbonylamino-3,3,3-trifluoro-2-[(S)-phenyl-((R)-toluene-4-sulfinyl)-methyl]-propionic acid methyl ester (184636-35-9)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃;

Reference yield:

trifluoroacetic anhydride (407-25-0) + (R)-2-Benzyloxycarbonylamino-3,3,3-trifluoro-2-[(R)-phenyl-((R)-toluene-4-sulfinyl)-methyl]-propionic acid methyl ester (184636-34-8) → (R)-2-Benzyloxycarbonylamino-3,3,3-trifluoro-2-((R)-phenyl-p-tolylsulfanyl-methyl)-propionic acid methyl ester (184636-44-0)

Guidance literature:

With sodium iodide; In acetone; at -20 ℃; for 0.0833333h;

Reference yield:

(R)-2-Benzyloxycarbonylamino-3,3,3-trifluoro-2-[(R)-phenyl-((R)-toluene-4-sulfinyl)-methyl]-propionic acid methyl ester (184636-34-8) → (R)-α-trifluoromethylphenylalanine

Guidance literature:

Multi-step reaction with 3 steps

1: NaI / acetone / 0.08 h / -20 °C

2: Raney-Ni, H₂ / ethanol / 3 h / Heating

3: 1.) 0.5 N KOH: 2.) 1 N HCl; 3.) DOWEX 50W-X₈ / 1.) MeOH, H₂O, r.t., 7 h; 3.) 7.5 percent aq. NH₃

With hydrogenchloride; potassium hydroxide; Dowex 50W-X₈; hydrogen; nickel; sodium iodide; In ethanol; acetone;

upstream raw materials:

2-benzyloxycarbonylimino-3,3,3-trifluoropropionic acid methyl ester

(R)-1-(benzylsulfinyl)-4-methylbenzene

Downstream raw materials:

(R)-2-Benzyloxycarbonylamino-3,3,3-trifluoro-2-((R)-phenyl-p-tolylsulfanyl-methyl)-propionic acid methyl ester

(R)-α-trifluoromethylphenylalanine methyl ester