Nebivolol

Base Information

• Chemical Name: Nebivolol
• CAS No.: 9920-09-6
• Molecular Formula: C22H25F2NO4
• Molecular Weight: 441.903
• Hs Code.: 2934999090
• Mol file: 9920-09-6.mol

Synonyms:Diafen hydrochloride;Hispril hydrochloride;Diaphen;diphenylpyraline HCl;4-benzhydryloxy-1-methyl-piperidine,hydrochloride;Belfene hydrochloride;Sumadil;Allerzine;diphenylpyraline;d,l-nebivolol hydrochloride;4-Benzhydryloxy-1-methyl-piperidin,Hydrochlorid;4-diphenylmethoxy-1-methyl-piperidine hydrochloride;Lergoban;Histalert;Neargal hydrochloride;Diphenylpyraline hydrochloride;

Chemical Property of Nebivolol

Chemical Property:

• PSA: 70.95000
• LogP: 2.75450

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Nebivolol

There total 7 articles about Nebivolol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.2%

nebivolol (99200-09-6,118457-14-0,118457-15-1,119365-25-2,119365-23-0,1360598-84-0) → α,α'-iminobis(methylene)bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride (9920-09-6,152520-56-4,920299-33-8)

Guidance literature:

With hydrogenchloride; In methanol; at 25 - 35 ℃;

Reference yield:

6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid (99199-60-7,129050-20-0) → α,α'-iminobis(methylene)bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride (9920-09-6,152520-56-4,920299-33-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate; sulfuric acid / diethyl ether; tetrahydrofuran / 0.75 h / 0 - 35 °C

1.2: pH 7

2.1: sodium hydrogencarbonate / iodine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 0.17 h / 20 °C

2.2: 24 h / 20 - 25 °C

3.1: sodium hydride / dimethyl sulfoxide / 0.5 h

3.2: 1 h / 20 - 25 °C

4.1: isopropyl alcohol / Reflux

5.1: ammonium formate / palladium 10% on activated carbon / methanol / 3 h / Reflux

6.1: hydrogenchloride / methanol / 25 - 35 °C

With hydrogenchloride; sodium tetrahydroborate; sulfuric acid; ammonium formate; sodium hydride; sodium hydrogencarbonate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium 10% on activated carbon; iodine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol (99199-62-9) → α,α'-iminobis(methylene)bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride (9920-09-6,152520-56-4,920299-33-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / iodine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 0.17 h / 20 °C

1.2: 24 h / 20 - 25 °C

2.1: sodium hydride / dimethyl sulfoxide / 0.5 h

2.2: 1 h / 20 - 25 °C

3.1: isopropyl alcohol / Reflux

4.1: ammonium formate / palladium 10% on activated carbon / methanol / 3 h / Reflux

5.1: hydrogenchloride / methanol / 25 - 35 °C

With hydrogenchloride; ammonium formate; sodium hydride; sodium hydrogencarbonate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium 10% on activated carbon; iodine; In methanol; dichloromethane; dimethyl sulfoxide; isopropyl alcohol;

upstream raw materials:

α,α'-[[(phenylmethyl)imino]bismethylene]bis-[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]

6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid

nebivolol

6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol

Downstream raw materials:

nebivolol