ethyl 5-(4-chlorophenyl)-2-[4-(dimethylamino)benzylidene]-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

Base Information

Chemical Name:ethyl 5-(4-chlorophenyl)-2-[4-(dimethylamino)benzylidene]-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS No.:154867-11-5
Molecular Formula:C₂₅H₂₄ClN₃O₃S
Molecular Weight:482.003
Hs Code.:
Mol file:154867-11-5.mol

ethyl 5-(4-chlorophenyl)-2-[4-(dimethylamino)benzylidene]-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

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Chemical Property of ethyl 5-(4-chlorophenyl)-2-[4-(dimethylamino)benzylidene]-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

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Technology Process of ethyl 5-(4-chlorophenyl)-2-[4-(dimethylamino)benzylidene]-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

There total 9 articles about ethyl 5-(4-chlorophenyl)-2-[4-(dimethylamino)benzylidene]-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 154866-92-9
ethyl 4-(4-chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-thioxopyrimidine-5-carboxylate

: 79-11-8
chloroacetic acid

: 100-10-7
4-dimethylamino-benzaldehyde

: 154867-11-5
ethyl 5-(4-chloroyphenyl)-2-<4-(N,N-dimethylamino)phenylmethylene>-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo<3,2-a>pyrimidine-6-carboxylate

Guidance literature:: With sodium acetate; In acetic anhydride; acetic acid; for 3h; Heating;
DOI:10.1016/S0040-4020(01)80225-8

Reference yield: 62.0%

: 100-10-7
4-dimethylamino-benzaldehyde

: 181058-43-5
ethyl 5-(4-chlorophenyl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate

: 154867-11-5
5-(4-Chloro-phenyl)-2-[1-(4-dimethylamino-phenyl)-meth-(Z)-ylidene]-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester

Guidance literature:: With sodium acetate; acetic acid; for 2h; Heating;
DOI:10.1080/10426509608029657

Reference yield:

: 141-97-9
ethyl acetoacetate

: 154867-11-5
5-(4-Chloro-phenyl)-2-[1-(4-dimethylamino-phenyl)-meth-(Z)-ylidene]-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / conc. HCl / ethanol / 3 h / Heating

2: NaOAc, AcOH, Ac₂O / 2 h / Heating

With hydrogenchloride; sodium acetate; acetic anhydride; acetic acid; In ethanol;
DOI:10.1080/10426509608029657