154866-92-9

Upstream product

• 141-97-9 ethyl acetoacetate 
• 104-88-1 4-chlorobenzaldehyde 
• 17356-08-0 thiourea 
• 13086-93-6 (acetyloxy)(4-chlorophenyl)methyl acetate 
• 873-76-7 para-Chlorobenzyl alcohol 
• 1147550-11-5 ammonium thiocyanate 

Downstream Products

• 154866-96-3 ethyl 3-amino-5-(4-chlorophenyl)-2-cyano-7-methyl-5H-thiazolo<3,2-a>pyrimidine-6-carboxylate 
• 154867-11-5 ethyl 5-(4-chloroyphenyl)-2-<4-(N,N-dimethylamino)phenylmethylene>-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo<3,2-a>pyrimidine-6-carboxylate 
• 1034918-25-6 ethyl 5-(4-chlorophenyl)-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1117816-31-5 C₃₀H₂₂Cl₂N₄O₄ 
• 1104612-58-9 4-(4-chloro-phenyl)-6-methyl-2-pentylsulfanyl-1, 4-dihydro-pyrimidine-5-carboxylic acid ethyl ester 
• 337378-45-7 ethyl 4-(4-chlorophenyl)-1,4-dihydro-6-methyl-2-(methylthio)pyrimidine-5-carboxylate 
• 1296205-32-7 ethyl 6-(4-chlorophenyl)-1-(ethoxymethyl)-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxylate 
• 1301742-03-9 C₂₈H₂₆Cl₂N₄O₄S 
• 367907-08-2 ethyl 7-(4-chlorophenyl)-5-methyl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate 
• 856436-83-4 C₁₆H₁₇ClN₂O₃S 
• 948199-82-4 C₁₄H₁₃ClN₂O₂S 
• 1420034-60-1 ethyl 5-(4-chlorophenyl)-7-methyl-3-pentyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1421829-32-4 ethyl 2-(4-bromophenylthio)-4-(4-chlorophenyl)-6-methylpyrimidine-5-carboxylate 
• 1421829-22-2 ethyl 4-(4-chlolophenyl)-6-methyl-2-(phenylthio)pyrimidine-5-carboxylate 

Relevant academic research and scientific papers

Glycerol as an alternative green reaction medium for multicomponent reactions using PS-PEG-OSO3H as catalyst

Development of green solvents from renewable resources has gained much attention recently, because of the extensive uses of solvents in almost all of the chemical industry and the predicted disappearance of fossil oil. Here we show that glycerol and PS-PE

Ruthenium(III) chloride-catalyzed one-pot synthesis of 3,4- dihydropyrimidin-2-(1H)-ones under solvent-free conditions

Ruthenium(III) chloride efficiently catalyzes the three-component Biginelli reaction of an aldehyde, a β-keto ester, and urea or thiourea under solvent-free conditions to afford the corresponding 3,4-dihydropyrimidine-2-(1H) -ones in excellent yields. Geo

Biginelli reaction in aqueous medium: a greener and sustainable approach to substituted 3,4-dihydropyrimidin-2(1H)-ones

An environmentally benign aqueous Biginelli protocol for the synthesis of substituted 3,4-dihydropyrimidin-2(1H)-ones using polystyrenesulfonic acid (PSSA) as a catalyst has been achieved. These microwave-assisted reactions proceed efficiently in water in

Silica gel-supported polyphosphoric acid (PPA-SiO2) catalyzed one-pot multi-component synthesis of 3, 4-dihydropyrimidin-2(1H)-ones and -thiones: An efficient method for the Biginelli reaction

A green and efficient method for the synthesis of 3, 4-dihydropyrimidin- 2(1H)-ones and -thiones through one-pot three-component reaction of ethyl acetoacetate, an aryl aldehyde, and urea or thiourea in acetonitrile using silica gel-supported polyphosphor

Synthesis method of dihydropyrimidinone compound

The invention discloses a synthesis method of a dihydropyrimidone compound, which belongs to the technical field of organic synthesis, and comprises the following steps: by taking benzaldehyde or a derivative thereof, ethyl acetoacetate or acetylacetone a

Deep eutectic solvent assisted synthesis of dihydropyrimidinones/thionesviaBiginelli reaction: theoretical investigations on their electronic and global reactivity descriptors

Deep eutectic solvents formed from hydrated metal chlorides and hydrogen bond donors (Type 4) were prepared and their catalytic activity was compared for the synthesis of dihydropyrimidinones/thionesviaBiginelli reaction at room temperature. The one-pot m

Aiding the versatility of simple ammonium ionic liquids by the synthesis of bioactive 1,2,3,4-tetrahydropyrimidine, 2-aminothiazole and quinazolinone derivatives

Simple ammonium ionic liquids [ILs] are efficient, green, environmentally friendly catalysts in promoting the Biginelli condensation reaction, Hantzsch reaction and Niementowski reaction to afford 1,2,3,4-tetrahydropyrimidine, 2-aminothiazole and quinazolinone derivatives respectively by eliminating the need for harmful volatile organic solvents. These [ILs] are air and water stable, easy to prepare and cost-effective. The effects of the anions and cations present in [IL] on reactions were investigated. The results clearly indicated that the Biginelli condensation reaction, Hantzsch reaction and Niementowski reaction were heavily influenced by the acidity of [IL], and among various ammonium ionic liquids, [Et3NH][HSO4] showed the best catalytic activity. Furthermore, [IL] could be easily separated and reused with a slight loss of its activity. This technique provided a good alternative way for the industrial synthesis of 1,2,3,4-tetrahydropyrimidinones, 2-aminothiazoles and quinazolinones. The present processes are eco-friendly methods for the synthesis of these derivatives authenticated by several green parameters, namely,E-factor, process mass intensity, reaction mass efficiency, atom economy, and carbon efficiency.

Sulfonic Acid and Ionic Liquid Functionalized Covalent Organic Framework for Efficient Catalysis of the Biginelli Reaction

A quinoline-linked and ionic liquid-decorated covalent organic framework was prepared by incorporation of a multicomponent Povarov reaction and postsynthetic modification. The imidazolium and sulfonic acid-decorated COF-IM-SO3H can be a highly efficient B

Poly(N-vinyl-2-pyrrolidone)-supported ferric chloride: An effective reusable heterogeneous catalyst for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via three-component Biginelli reaction

An environmentally benign three-component Biginelli protocol for the one-pot synthesis of substituted 3,4-dihydropyrimidin-2(1H)-ones/thiones using an accessible, nontoxic, easy to handle, and recoverable macromolecular Lewis acidic catalyst is developed.

Amino acid ionic liquid-catalyzed synthesis, anti-Leishmania activity, molecular docking, molecular dynamic simulation, and ADME study of 3,4-dihydropyrimidin-2(1H)-(thio)ones

The synthesis of 3,4-dihydropyrimidin-2(1H)-(thio)one (DHPM) derivatives involving aromatic aldehyde, β-ketoesters and urea/thiourea using prolinium hydrogen sulfate (ProHSO4) as a catalyst has been studied. A variety of DHPM derivatives were o