4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 343306-50-3
• Molecular Formula: C16H22N2O4
• Molecular Weight: 306.362
• Hs Code.: 2933599090
• Mol file: 343306-50-3.mol

Synonyms:4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Boc-4-(3-ForMyl-4-hydroxyphenyl)piperazine;tert-Butyl 4-(3-forMyl-4-hydroxyphenyl)piperazine-1-carboxylate

Chemical Property of 4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 463.404°C at 760 mmHg
• Flash Point: 234.059°C
• PSA: 70.08000
• Density: 1.225g/cm³
• LogP: 2.26470
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(3-formyl-4-hydroxyphenyl)piperazine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 4 articles about 4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-t-Butoxycarbonylpiperazine (57260-71-6) + 5-bromosalicylaldehyde dimethyl acetal (501085-54-7) → 4-(3-formyl-4-hydroxyphenyl)piperazine-1-carboxylic acid tert-butyl ester (343306-50-3)

Guidance literature:

2-hydroxy-5-bromobenzaldehyde dimethyl acetal; With sodium methylate; In methanol; at 25 ℃; for 2h;

1-t-Butoxycarbonylpiperazine; With copper(l) iodide; potassium carbonate; L-proline; In 1,4-dioxane; at 105 ℃; for 5h; Reagent/catalyst; Inert atmosphere;

Reference yield: 56.0%

5-bromosalicyclaldehyde (1761-61-1) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 4-(3-formyl-4-hydroxyphenyl)piperazine-1-carboxylic acid tert-butyl ester (343306-50-3)

Guidance literature:

5-bromosalicyclaldehyde; 1-t-Butoxycarbonylpiperazine; With sodium t-butanolate; tri-tert-butyl phosphine; palladium diacetate; In toluene; at 42 ℃; for 22h; Inert atmosphere;

With acetic acid; In water; toluene; for 0.166667h;

Reference yield: 51.0%

tri-tert-butyl phosphine (13716-12-6) + 5-bromosalicyclaldehyde (1761-61-1) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 4-(3-formyl-4-hydroxyphenyl)piperazine-1-carboxylic acid tert-butyl ester (343306-50-3)

Guidance literature:

With sodium t-butanolate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In n-heptane; water; toluene;

upstream raw materials:

5-bromosalicyclaldehyde

1-t-Butoxycarbonylpiperazine

tri-tert-butyl phosphine

5-bromosalicylaldehyde dimethyl acetal