N-[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-cyano-5-methylbenzenesulfonamide

Base Information

• Chemical Name: N-[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-cyano-5-methylbenzenesulfonamide
• CAS No.: 1426214-86-9
• Molecular Formula: C₁₉H₁₅N₇O₂S
• Molecular Weight: 405.44
• Mol file: 1426214-86-9.mol

Synonyms:N-[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-cyano-5-methylbenzenesulfonamide

Chemical Property of N-[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-cyano-5-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-cyano-5-methylbenzenesulfonamide

There total 6 articles about N-[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-cyano-5-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-carbamic acid tert-butyl ester (1426214-89-2) + 2-cyano-5-methylbenzene-1-sulfonyl chloride (197960-31-9) → N-[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-cyano-5-methylbenzenesulfonamide (1426214-86-9)

Guidance literature:

[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-carbamic acid tert-butyl ester; With hydrogenchloride; In water; at 20 ℃; for 2h;

2-cyano-5-methylbenzene-1-sulfonyl chloride; With pyridine; at 100 ℃; for 1h; Sealed tube;

Reference yield:

C11H10N6 (1426215-67-9) + 2-cyano-5-methylbenzene-1-sulfonyl chloride (197960-31-9) + trifluoroacetic acid (76-05-1) → N-[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-cyano-5-methylbenzenesulfonamide (1426214-86-9)

Guidance literature:

C₁₁H₁₀N₆; 2-cyano-5-methylbenzene-1-sulfonyl chloride; With pyridine; at 100 ℃; for 1h; Sealed tube;

trifluoroacetic acid; In N,N-dimethyl-formamide;

Reference yield:

3,5-dichloro-pyrazine-2-carbonitrile (313339-92-3) → N-[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2-cyano-5-methylbenzenesulfonamide (1426214-86-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 100 °C

2.1: hydrazine / water; isopropyl alcohol / 1.17 h / 120 °C / Microwave irradiation

3.1: hydrogenchloride / water / 2 h / 20 °C

3.2: 1 h / 100 °C / Sealed tube

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; hydrazine; In 1,4-dioxane; water; isopropyl alcohol;

upstream raw materials:

[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-carbamic acid tert-butyl ester

2-cyano-5-methylbenzene-1-sulfonyl chloride

3,5-dichloro-pyrazine-2-carbonitrile

[4-(6-chloro-5-cyanopyrazine-2-yl)phenyl]aminoformic acid tert-butyl ester