quinoline-6-carbonitrile

Base Information

• Chemical Name: quinoline-6-carbonitrile
• CAS No.: 23395-72-4
• Molecular Formula: C10H6N2
• Molecular Weight: 154.171
• Hs Code.: 2933499090
• Mol file: 23395-72-4.mol

Synonyms:quinoline-6-carbonitrile;6-Quinolinecarbonitrile;Quinolin-6-carbonitrile

Chemical Property of quinoline-6-carbonitrile

Chemical Property:

• Vapor Pressure: 0.000258mmHg at 25°C
• Melting Point: 133-134℃ (methanol )
• Refractive Index: 1.654
• Boiling Point: 323.7 °C at 760 mmHg
• PKA: 3.50±0.10(Predicted)
• Flash Point: 115.5 °C
• PSA: 36.68000
• Density: 1.21g/cm³
• LogP: 2.10648
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

6-Cyanoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-41
• Safety Statements: 26-39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Cyanoquinoline is used in the preparation of aromatic nitriles.

Technology Process of quinoline-6-carbonitrile

There total 39 articles about quinoline-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

6-(hydroxymethyl)quinoline (100516-88-9) → quinoline-6-carbonitrile (23395-72-4)

Guidance literature:

With ammonia; oxygen; In tert-Amyl alcohol; water; at 100 ℃; for 4h; under 3750.38 Torr; Autoclave; High pressure;

DOI:10.1021/acscatal.0c00485

Reference yield: 96.0%

6-chloroquinoline (612-57-7) + potassiumhexacyanoferrate(II) trihydrate → quinoline-6-carbonitrile (23395-72-4)

Guidance literature:

With 2-[2-(dicyclohexylphosphino)-phenyl]-1-methyl-1H-indole; palladium diacetate; sodium carbonate; triethylamine; In water; acetonitrile; at 70 ℃; for 18h;

DOI:10.1021/ol1028892

Reference yield: 96.0%

quinolin-6-yl methanesulfonate (1092513-18-2) + dicyanozinc (557-21-1) → quinoline-6-carbonitrile (23395-72-4)

Guidance literature:

With palladium diacetate; PS-triphenylphosphine; In tetrahydrofuran; at 120 ℃; for 1.5h;

DOI:10.1080/00397910601039044

upstream raw materials:

6-aminoquinoline

potassium cyanide

quinolin-6-yl methanesulfonate

dicyanozinc

Downstream raw materials:

quinoline-6-carboxamide

Quinoline-6-carboxylic acid

quinolin-6-ylmethanamine

6-((5-Phenoxy-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)methyl)quinoline