2-chloro-4-(cyclopentylamino)-5-pyrimidinyl ethanone

Base Information Edit

Chemical Name:2-chloro-4-(cyclopentylamino)-5-pyrimidinyl ethanone
CAS No.:1244949-62-9
Molecular Formula:C₁₁H₁₄ClN₃O
Molecular Weight:239.705
Hs Code.:
Mol file:1244949-62-9.mol

Synonyms:

Suppliers and Price of 2-chloro-4-(cyclopentylamino)-5-pyrimidinyl ethanone

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-[2-Chloro-4-(cyclopentylamino)-5-pyrimidinyl]ethanone
100mg
$ 155.00

Total 5 raw suppliers

Chemical Property of 2-chloro-4-(cyclopentylamino)-5-pyrimidinyl ethanone Edit

Chemical Property:

Boiling Point:442.1±30.0 °C(Predicted)
PKA:0.84±0.10(Predicted)
Density:1.305±0.06 g/cm3(Predicted)

Purity/Quality:

95% ^*data from raw suppliers

1-[2-Chloro-4-(cyclopentylamino)-5-pyrimidinyl]ethanone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 1-[2-Chloro-4-(cyclopentylamino)-5-pyrimidinyl]ethanone acts as a reagent for the preparation of Palbociclib, a drug for the treatment of ER-positive and HER-negative breast cancer development.

Technology Process of 2-chloro-4-(cyclopentylamino)-5-pyrimidinyl ethanone

There total 2 articles about 2-chloro-4-(cyclopentylamino)-5-pyrimidinyl ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 2-chloro-4-(cyclopentylamino)pyrimidine

: 75-05-8,26809-02-9
acetonitrile

: 1244949-62-9
C₁₁H₁₄ClN₃O

Guidance literature:: With boron trichloride; In dichloromethane; 1,2-dichloro-ethane; at 0 - 5 ℃; Reflux;

Reference yield:

: 1003-03-8
Cyclopentamine

: 1244949-62-9
C₁₁H₁₄ClN₃O

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: boron trichloride / dichloromethane; 1,2-dichloro-ethane / 0 - 5 °C / Reflux

With boron trichloride; triethylamine; In dichloromethane; 1,2-dichloro-ethane;