N-((1S,2S)-2-Amino-1,2-diphenylethyl)methanesulfonamide

Base Information

• Chemical Name: N-((1S,2S)-2-Amino-1,2-diphenylethyl)methanesulfonamide
• CAS No.: 300345-76-0
• Molecular Formula: C15H18N2O2S
• Molecular Weight: 290.386
• European Community (EC) Number: 679-410-2
• DSSTox Substance ID: DTXSID60459313
• Nikkaji Number: J2.092.706B
• Wikidata: Q82283057
• Mol file: 300345-76-0.mol

Synonyms:300345-76-0;N-((1S,2S)-2-Amino-1,2-diphenylethyl)methanesulfonamide;N-[(1S,2S)-2-amino-1,2-diphenylethyl]methanesulfonamide;(1S,2S)-N-Methylsulfonyl-1,2-diphenylethanediamine;N-[(1S,2S)-2-Amino-1,2-diphenylethyl]methanesulfon amide;SCHEMBL3856755;DTXSID60459313;MFCD03791037;AKOS015896093;AS-70157;CS-0133276;(1S,2S)-N-Mesyl-1,2-diphenylethylenediamine;W18888;(1S,2S)-N-Methanesulfonyl-1,2-diphenylethanediamine, AldrichCPR

Chemical Property of N-((1S,2S)-2-Amino-1,2-diphenylethyl)methanesulfonamide

Chemical Property:

• Melting Point: 118-120°C
• PSA: 80.57000
• LogP: 4.14890
• Sensitive.: Air Sensitive
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 290.10889899
• Heavy Atom Count: 20
• Complexity: 379

Purity/Quality:

97% ^*data from raw suppliers

N-[(1S,2S)-2-Amino-1,2-diphenylethyl]methanesulfonamide 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CS(=O)(=O)NC(C1=CC=CC=C1)C(C2=CC=CC=C2)N
• Isomeric SMILES: CS(=O)(=O)N[C@@H](C1=CC=CC=C1)[C@H](C2=CC=CC=C2)N

Technology Process of N-((1S,2S)-2-Amino-1,2-diphenylethyl)methanesulfonamide

There total 1 articles about N-((1S,2S)-2-Amino-1,2-diphenylethyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(S,S)-1,2-diphenyl-1,2-diaminoethane (29841-69-8) + methanesulfonyl chloride (124-63-0) → (1S,2S)-N-methanesulfonyl-1,2-diphenylethane-1,2-diamine (300345-76-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 12h; Cooling with ice;

DOI:10.1039/c0ob00757a

Reference yield: 99.0%

bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] (12354-84-6,12354-85-7) + (1S,2S)-N-methanesulfonyl-1,2-diphenylethane-1,2-diamine (300345-76-0) → Cp*IrCl[(S,S)-MsDPEN]

Guidance literature:

With triethylamine; In isopropyl alcohol; at 20 ℃; for 7h;

Reference yield: 99.0%

(1S,2S)-N-methanesulfonyl-1,2-diphenylethane-1,2-diamine (300345-76-0) + (R)-3-(5-(tert-butyl)-3-formyl-2-hydroxybenzyl)-1-(2'-hydroxy-[1,1'-binaphthalen]-2-yl)-1H-imidazol-3-ium chloride → 3-(5-(tert-butyl)-3-((E)-(((1S,2S)-1,2-diphenyl-2-(methylsulfonamido)ethyl)imino)methyl)-2-hydroxybenzyl)-1-((R)-2'-hydroxy-[1,1'-binaphthalen]-2-yl)-1H-imidazol-3-ium chloride

Guidance literature:

In dichloromethane; at 20 ℃; for 18h; Molecular sieve; Inert atmosphere;

DOI:10.1002/anie.202009093

upstream raw materials:

(S,S)-1,2-diphenyl-1,2-diaminoethane

methanesulfonyl chloride

Downstream raw materials:

C₃₆H₄₁N₅O₃S₂

N-((1S,2S)-2-(3-((1R)-(6-methoxyquinolin-4-yl)((2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thioureido)-1,2-diphenylethyl)methanesulfonamide

N-((1S,2S)-2-(3-((S)-3,3-dimethyl-1-(pyrrolidin-1-yl)butan-2-yl)thioureido)-1,2-diphenylethyl)methanesulfonamide

N-((1S,2S)-1,2-diphenyl-2-(2-(tetrahydro-2H-pyran-2-yloxy)ethylamino)ethyl)methanesulfonamide