ethyl 6-vinylpicolinate

Base Information

• Chemical Name: ethyl 6-vinylpicolinate
• CAS No.: 1383474-28-9
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.203
• Mol file: 1383474-28-9.mol

Synonyms:

Chemical Property of ethyl 6-vinylpicolinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 6-vinylpicolinate

There total 3 articles about ethyl 6-vinylpicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ ethyl 6-vinylpicolinate (1383474-28-9)

Guidance literature:

Reference yield: 76.21%

tri-n-butyl(vinyl)tin (7486-35-3) + 6-chloropyridine-2-carboxylic acid ethyl ester (21190-89-6) → ethyl 6-vinylpicolinate (1383474-28-9)

Guidance literature:

tri-n-butyl(vinyl)tin; 6-chloropyridine-2-carboxylic acid ethyl ester; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 110 - 120 ℃; for 3h;

With potassium fluoride; for 0.5h; Cooling;

Reference yield: 76.0%

2,4,6,8-tetramethyl-2,4,6,8-tetravinyl-cyclotetrasiloxane (2554-06-5) + 6-chloropyridine-2-carboxylic acid ethyl ester (21190-89-6) → ethyl 6-vinylpicolinate (1383474-28-9)

Guidance literature:

With XPhos; tetrabutyl ammonium fluoride; palladium diacetate; In tetrahydrofuran; at 67 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201802573

upstream raw materials:

2,4,6,8-tetramethyl-2,4,6,8-tetravinyl-cyclotetrasiloxane

6-chloropyridine-2-carboxylic acid ethyl ester

tri-n-butyl(vinyl)tin

Downstream raw materials:

Ethyl 6-Ethyl-2-pyridinecarboxylate