tert-butyl 2-bromo-5-chlorobenzoate

Base Information

• Chemical Name: tert-butyl 2-bromo-5-chlorobenzoate
• CAS No.: 916904-25-1
• Molecular Formula: C₁₁H₁₂BrClO₂
• Molecular Weight: 291.572
• Mol file: 916904-25-1.mol

Synonyms:

Chemical Property of tert-butyl 2-bromo-5-chlorobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-bromo-5-chlorobenzoate

There total 1 articles about tert-butyl 2-bromo-5-chlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-5-chlorobenzoic acid (21739-93-5) + tert-butyl alcohol (75-65-0) → tert-butyl 2-bromo-5-chlorobenzoate (916904-25-1)

Guidance literature:

With sulfuric acid; magnesium sulfate; at 20 ℃;

DOI:10.1016/j.bmc.2006.08.010

Reference yield:

tert-butyl 2-bromo-5-chlorobenzoate (916904-25-1) → 2'-(3-carbamoyl-phenylcarbamoyl)-4'-chloro-biphenyl-2-carboxylic acid

Guidance literature:

Multi-step reaction with 6 steps

1: 3.25 g / K₃PO₄ / Pd(PPh₃)4 / dimethylformamide / 3 h / 100 °C

2: NaH₂PO₄*2H₂O; 2-methyl-2-butene; sodium chlorite / 2-methyl-propan-2-ol; H₂O; acetonitrile / 9 h / 20 °C

3: 3.32 g / K₂CO₃ / dimethylformamide / 3 h / 20 °C

4: trifluoroacetic acid / CH₂Cl₂

5: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 12 h / 20 °C

6: 367 mg / NaOH / methanol; H₂O / 12 h / Heating

With sodium hydroxide; sodium chlorite; potassium phosphate; sodium dihydrogenphosphate; 2-methyl-but-2-ene; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 1: Suzuki coupling;

DOI:10.1016/j.bmc.2006.08.010

Reference yield:

tert-butyl 2-bromo-5-chlorobenzoate (916904-25-1) → 2'-(3-carbamoyl-phenylcarbamoyl)-4'-chloro-4-isobutylcarbamoyl-biphenyl-2-carboxylic acid methyl ester

Guidance literature:

Multi-step reaction with 5 steps

1: K₃PO₄ / Pd(PPh₃)4 / dimethylformamide / 24 h / 120 °C

2: NaH₂PO₄*2H₂O; 2-methyl-2-butene; sodium chlorite / 2-methyl-propan-2-ol; H₂O; acetonitrile / 12 h / 20 °C

3: 185 mg / K₂CO₃ / dimethylformamide / 12 h / 20 °C

4: trifluoroacetic acid / CH₂Cl₂ / 20 °C

5: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 12 h / 60 °C

With sodium chlorite; potassium phosphate; sodium dihydrogenphosphate; 2-methyl-but-2-ene; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 1: Suzuki coupling;

DOI:10.1016/j.bmc.2006.08.010

upstream raw materials:

2-bromo-5-chlorobenzoic acid

tert-butyl alcohol