Technology Process of C29H25ClN2O5
There total 16 articles about C29H25ClN2O5 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Resolution of racemate;
- Guidance literature:
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Multi-step reaction with 8 steps
1.1: sodium tetrahydroborate / tetrahydrofuran / 0.5 h / 20 °C
2.1: thionyl chloride / dichloromethane
3.1: titanium tetrachloride / dichloromethane / 5 h / 20 °C
4.1: hydrogenchloride / 12 h / Reflux
5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane / 12 h / 90 °C / Inert atmosphere
6.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,4-dioxane / 3 h / 80 °C / Inert atmosphere
7.1: lithium hydroxide; water / methanol / 1 h / 60 °C
7.2: pH Ca. 3
8.1: Resolution of racemate
With
hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; thionyl chloride; water; titanium tetrachloride; sodium carbonate; lithium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: thionyl chloride / dichloromethane
2.1: titanium tetrachloride / dichloromethane / 5 h / 20 °C
3.1: hydrogenchloride / 12 h / Reflux
4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane / 12 h / 90 °C / Inert atmosphere
5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,4-dioxane / 3 h / 80 °C / Inert atmosphere
6.1: lithium hydroxide; water / methanol / 1 h / 60 °C
6.2: pH Ca. 3
7.1: Resolution of racemate
With
hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; thionyl chloride; water; titanium tetrachloride; sodium carbonate; lithium hydroxide;
In
1,4-dioxane; methanol; dichloromethane; water;