34598-50-0Relevant articles and documents
Thrombin inhibitors based on [5,5] trans-fused indane lactams
Pass, Martin,Abu-Rabie, Said,Baxter, Andrew,Conroy, Richard,Coote, Steven J.,Craven, Andrew P.,Finch, Harry,Hindley, Sean,Kelly, Henry A.,Lowdon, Andrew W.,McDonald, Edward,Mitchell, William L.,Pegg, Neil A.,Procopiou, Pan A.,Ramsden, Nigel G.,Thomas, Rhian,Walker, Dawn A.,Watson, Nigel S.,Jhoti, Harren,Mooney, Christopher J.,Tang, Chi-Man,Thomas, Pamela J.,Parry, Simon,Patel, Champa
, p. 1657 - 1662 (1999)
A series of trans-fused lactams containing the indane nucleus has been prepared. Compound 19 has much enhanced plasma stability compared with its lactone counterpart and shows appreciable in vitro anticoagulant activity.
Kinetic resolution of racemic benzofused alcohols catalysed by HMFO variants in presence of natural deep eutectic solvents
Fraaije, Marco,Lon?ar, Nikola,de Gonzalo, Gonzalo
, (2022/03/01)
5-Hydroxymethylfurfural oxidase (HMFO) has demonstrated to be a useful biocatalyst for the selective oxidation of alcohols employing oxygen as mild oxidant with no requirement of expensive organic cofactors. This wild-type HMFO biocatalyst and an engineered thermostable variant have been tested in the kinetic resolution of different benzofused alcohols. The use of natural deep eutectic solvents was also explored in HMFO-catalysed oxidation of alcohols. The oxidation of racemic 1-indanol showed a higher conversion and selectivity in presence of 60% v/v of different NADES, especially for those containing carbohydrates. By choosing properly the biocatalyst and the NADES, good enantioselectivity values can be obtained, demonstrating the advantages of employing these neoteric solvents in biocatalysed processes.
PERIPHERAL ALKYL AND ALKENYL CHAINS EXTENDED BENZENE DERIVATIVES AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME
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Paragraph 0063; 0164-0167, (2020/10/20)
The compounds represented by Formula (I), which are peripheral alkyl and alkenyl chains extended benzene derivatives, are useful as dual autotaxin (ATX) / histone deacetylase (HD AC) inhibitors. These compounds may be included in a pharmaceutical composition along with a pharmaceutically acceptable carrier, and be used in a therapeutically effective amount for prophylaxis or treatment of various diseases and disorders.
JAK kinase inhibitor and application
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Paragraph 0096-0097; 0099-0101, (2018/09/08)
The present invention discloses a compound having the following general formula (I). The present invention also discloses a JAK kinase inhibitor comprising the compound and application of the compoundin preparation of a medicament for treating JAK-associated diseases. The JAK kinase inhibitor can inhibit the biological activities of JAK1, JAK2, JAK3 and TYK2 kinases involved in various kinds of signal transduction, can effectively treat various inflammatory diseases and various JAK-mediated signal transduction-driven diseases, and has a very broad application prospect.