N-(9-{3-[1-(4-chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxy-acetamide

Base Information

• Chemical Name: N-(9-{3-[1-(4-chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxy-acetamide
• CAS No.: 908140-98-7
• Molecular Formula: C₄₃H₆₁ClN₆O₉Si₂
• Molecular Weight: 897.616
• Mol file: 908140-98-7.mol

Synonyms:

Chemical Property of N-(9-{3-[1-(4-chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxy-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(9-{3-[1-(4-chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxy-acetamide

There total 4 articles about N-(9-{3-[1-(4-chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxy-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane (69304-37-6) → N-(9-{3-[1-(4-chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxy-acetamide (908140-98-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / acetonitrile

2: DCA / CH₂Cl₂

With pyridine; dichloro-acetic acid; In dichloromethane; acetonitrile;

DOI:10.1081/NCN-200060150

Reference yield:

N2-(phenoxyacetyl)guanosine (119824-66-7) → N-(9-{3-[1-(4-chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxy-acetamide (908140-98-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / acetonitrile

2: DCA / CH₂Cl₂

With pyridine; dichloro-acetic acid; In dichloromethane; acetonitrile;

DOI:10.1081/NCN-200060150

Reference yield:

1-(4-Chlorophenyl)-4,4-diethoxypiperidine (263008-89-5) → N-(9-{3-[1-(4-chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxy-acetamide (908140-98-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Huenig's base; BF₃*Et₂O / CH₂Cl₂ / 0 °C

2: DCA / CH₂Cl₂

With dichloro-acetic acid; boron trifluoride diethyl etherate; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1081/NCN-200060150

upstream raw materials:

N²-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)guanosine

1-(4-Chlorophenyl)-4-ethoxy-1,2,5,6-tetrahydropyridine

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

N²-(phenoxyacetyl)guanosine

Downstream raw materials:

N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-[1-(4-chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxy-acetamide

N-(9-{3-[1-(4-chloro-phenyl)-4-ethoxy-piperidin-4-yloxy]-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxy-acetamide