119824-66-7

Basic information

• Product Name: N-(2-Phenoxyacetyl)guanosine
• Synonyms: N-(2-Phenoxyacetyl)guanosine;N2-Phenoxyacetylguanosine;N2-PAC-rG
• CAS NO: 119824-66-7
• Molecular Formula: C₁₈H₁₉N₅O₇
• Molecular Weight: 417.37276
• Mol File: 119824-66-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 159-160 °C
• Appearance: /
• Density: 1.76±0.1 g/cm3(Predicted)
• PKA: 8.97±0.20(Predicted)
• CAS DataBase Reference: N-(2-Phenoxyacetyl)guanosine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Phenoxyacetyl)guanosine(119824-66-7)
• EPA Substance Registry System: N-(2-Phenoxyacetyl)guanosine(119824-66-7)

Safety Data

• Hazardous Substances Data: 119824-66-7(Hazardous Substances Data)

Usage

Description

N-(2-Phenoxyacetyl)guanosine is a modified nucleoside chemical compound that features a guanosine base conjugated with a 2-phenoxyacetyl group. This unique structure endows it with potential applications in pharmaceutical and biochemical research, where its distinct properties could influence its interactions with biological systems. N-(2-Phenoxyacetyl)guanosine holds promise for therapeutic applications, particularly in the development of novel drugs to address a range of diseases. Further investigation into its characteristics and possible uses is essential to unlock its full potential.

Uses

Used in Pharmaceutical Research:
N-(2-Phenoxyacetyl)guanosine is used as a research compound for exploring its interactions with biological systems due to its unique structure and potential effects on various biological processes.
Used in Drug Development:
N-(2-Phenoxyacetyl)guanosine is utilized as a starting point for the development of new drugs, given its potential therapeutic applications in treating a variety of diseases, pending further research into its properties and efficacy.
Used in Biochemical Research:
In the field of biochemical research, N-(2-Phenoxyacetyl)guanosine is employed as a modified nucleoside to study its influence on biochemical pathways and mechanisms, which could lead to insights into disease processes and the discovery of new therapeutic targets.

Upstream product

• 701-99-5 Phenoxyacetyl chloride 
• 118-00-3 G 
• 34079-68-0 2,6-diamino-9-(β-D-arabinofuranosyl)-purine 
• 53274-35-4 2',3',5'-O-Trisguanosine 
• 14316-61-1 phenoxyacetic anhydride 
• 375345-66-7 phenoxyacetyl-1-O-benzotriazolide 

Downstream Products

• 1293390-55-2 N₂-(phenoxyacetyl)-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)guanosine 
• 1293390-63-2 N₂-(phenoxyacetyl)-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine 
• 1293390-67-6 N₂-(phenoxyacetyl)-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine 5'-[2-(2-nitrophenyl)propyl carbonate] 
• 1293390-74-5 N₂-(phenoxyacetyl)-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite) 5'-[2-(2-nitrophenyl)propyl carbonate] 
• 1032747-91-3 2',3',4'-tri-O-butyryl-2-N-(phenoxyacetyl)guanosin 
• 119824-68-9 Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-[6-oxo-2-(2-phenoxy-acetylamino)-1,6-dihydro-purin-9-yl]-4-triisopropylsilanyloxy-tetrahydro-furan-3-yl ester methyl ester 
• 119824-67-8 5'-monomethxytrityl-N²-phenoxyacetyl-2'-triisopropylsilylguanosine 
• 128191-50-4 5'-monomethxytrityl-N²-phenoxyacetyl-3'-triisopropylsilylguanosine 
• 121058-87-5 Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[6-oxo-2-(2-phenoxy-acetylamino)-1,6-dihydro-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 
• 121058-84-2 5′-O-(dimethoxytrityl)-2′-O-(tert-butyldimethylsilyl)-N2-phenoxyacetylguanosine 
• 121058-81-9 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N₂-phenoxyacetylguanosine 
• 863408-48-4 N²-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-cyanoethoxymethyl)guanosine 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite) 

Relevant articles and documents

Transient silylation of the guanosine O6 and amino groups facilitates N-acylation

(Matrix Presented) The formation of a guanosine derivative silylated at both the O6 and amino groups was identified by 15N NMR. This intermediate allows facile reaction with acetyl chloride or phenoxyacetyl chloride to give in high yield the co

Morpholino Nucleic Acid Derivatives

The present invention provides a useful morpholino nucleic acid derivative for synthesizing a morpholino nucleic acid oligomer. The present invention provides a compound represented by the following general formula (1) or a salt thereof. Here, R1 /s

High yield protection of purine ribonucleosides for phosphoramidite RNA synthesis

We report high yield procedures for protection of purine ribonucleosides based on a reaction which allows concomitant highly regiospecific 2'-silylation and 3'-phosphitylation. Subsequent cleavage of the H-phosphonate monoester moiety without silyl migration provides intermediates ready for phosphitylation by standard methods to give fully protected phosphoramidites.